The protective effect of L-carnitine on ionizing radiation-induced free oxygen radicals

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dc.authoridAkpolat Ferah, Meryem/0000-0002-3419-1728
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.authorwosidAkpolat Ferah, Meryem/ABD-3035-2020
dc.contributor.authorDokmeci, D.
dc.contributor.authorAkpolat, M.
dc.contributor.authorAydogdu, N.
dc.contributor.authorUzal, C.
dc.contributor.authorDoganay, L.
dc.contributor.authorTuran, F. N.
dc.date.accessioned2024-06-12T11:19:16Z
dc.date.available2024-06-12T11:19:16Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIonizing radiation is known to generate reactive oxygen species (ROS) that can be removed by antioxidants. L-carnitine, a natural component of mammalian tissue, is a necessary factor in the utilization of long-chain fatty acids to produce energy. Furthermore it has been shown that L-carnitine is an antioxidant which has a scavenger effect on ROS and a stabilizing effect on damaged cell membranes. The aim of the study was to evaluate the potential protective effect of L-carnitine on radiation-induced free radicals in hamsters. L-carnitine was given by gavage at a dose of 50 mg/kg for 15 consecutive days before irradiation with a single dose of 8 Gy. 24 h after radiation exposure, the hamsters were sacrificed and samples were taken from blood and tissues, and the biochemical and histopatological determinations were carried out. In the irradiated group, there were significant increases in plasma and liver malondialdehyde (MDA) with marked reduction in glutathione (GSH) levels in the liver, compared with controls. In red blood cells, superoxide dismutase (SOD) and catalase activities were also reduced. All these effects were reversed by L-carnitine. In conclusion, L-carnitine with its antioxidant and free radical scavenging properties could play a modulatory role against the cellular damage produced by free radicals induced by ionizing radiation.en_US
dc.identifier.endpage83en_US
dc.identifier.issn0901-3393
dc.identifier.issn2002-0112
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-33746553772en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25148
dc.identifier.volume33en_US
dc.identifier.wosWOS:000239539400002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherScandinavian Soc Laboratory Animal Scienceen_US
dc.relation.ispartofScandinavian Journal Of Laboratory Animal Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectL-Propionyl-Carnitineen_US
dc.subjectInduced Lipid-Peroxidationen_US
dc.subjectOxidative Stressen_US
dc.subjectDamageen_US
dc.subjectSupplementationen_US
dc.subjectErythrocytesen_US
dc.subjectLipoproteinsen_US
dc.subjectSuperoxideen_US
dc.subjectMetabolismen_US
dc.subjectAnemiaen_US
dc.titleThe protective effect of L-carnitine on ionizing radiation-induced free oxygen radicalsen_US
dc.typeArticleen_US

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