BRAF V600 Mutation Profile of Metastatic Melanoma in the Thrace Region of Turkey

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dc.authoridOz Puyan, Fulya/0000-0001-5853-0109
dc.authoridKöstek, Osman/0000-0002-1901-5603
dc.authoridPuyan, Fulya/0000-0001-5853-0109
dc.authoridCezik, Mert/0000-0003-1208-1656
dc.authorwosidOz Puyan, Fulya/A-7077-2018
dc.authorwosidCan, Nuray/D-3452-2016
dc.authorwosidKorkmaz, Selma/JRX-3713-2023
dc.authorwosidKöstek, Osman/AAA-3604-2019
dc.authorwosidPuyan, Fulya/V-7074-2019
dc.authorwosidKorkmaz, Selma/W-4142-2017
dc.contributor.authorCan, Nuray
dc.contributor.authorTastekin, Ebru
dc.contributor.authorDeniz Yalta, Tulin
dc.contributor.authorSut, Necdet
dc.contributor.authorKorkmaz, Selma
dc.contributor.authorUsta, Ufuk
dc.contributor.authorOz Puyan, Fulya
dc.date.accessioned2024-06-12T11:08:02Z
dc.date.available2024-06-12T11:08:02Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: BRAF is the most common mutation in melanoma. The most common subtype is BRAF V600E, followed by V600K. Initially, the authors aimed to investigate whether clinicopathological features of melanoma are associated with BRAF mutations. We then aimed to present the relationships between the clinicopathological features and the mutated subtype (V600E vs V600K). Material and Method: 61 patients with metastatic malignant melanoma (affecting the lymph node or other distant sites) were selected. Patient data regarding age at the time of diagnosis, sex, metastatic site (lymph node, distant metastasis or both) and primary tumour site were obtained from the hospital's database. Tissue samples containing at least 30% tumour cells were isolated from the specimens of 61 patients (24 samples from primary tumours and 37 from metastatic foci) for BRAF analysis. Comparisons between the BRAF V600 mutation and clinicopathological and histopathological features were performed. Results: BRAF V600 mutation was detected in 34 (55.7%) patients. The subtype was BRAF V600E in 22 (64.7%) patients, BRAF V600K in 11(32.4%) patients and BRAF V600R in 1(2.9%) patient. The crucial results of the present study may be summarized as follows: i) BRAF V600 mutation was more common in older patients and tumors with BRAF V600 mutation revealed necrosis and LVI more commonly than wild-type tumors, ii) BRAF V600K mutation was more common in older patients and BRAF V600K mutated tumors exhibited ulceration more commonly than tumors with BRAF V600E mutation (close to significant). Conclusion: The BRAF V600 mutation may have interactions with prognostic clinicoptahological features of melanoma including necrosis and lymphovascular invasion. V600K mutation may be more common than expected and may have different associations with properties of the tumor such as tumor ulceration and patient age. Investigation of the mutated subtype of the BRAF gene may therefore reveal more detailed data about the management of melanoma and may also prevent missing of candidates for BRAF inhibitor therapies.en_US
dc.identifier.doi10.5146/tjpath.2018.01422
dc.identifier.endpage142en_US
dc.identifier.issn1018-5615
dc.identifier.issn1309-5730
dc.identifier.issue2en_US
dc.identifier.pmid29419849en_US
dc.identifier.scopus2-s2.0-85046543925en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage134en_US
dc.identifier.trdizinid274343en_US
dc.identifier.urihttps://doi.org/10.5146/tjpath.2018.01422
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/274343
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22283
dc.identifier.volume34en_US
dc.identifier.wosWOS:000436622700003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherDe Gruyter Poland Sp Zooen_US
dc.relation.ispartofTurkish Journal Of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMalignant Melanomaen_US
dc.subjectBRAF Mutationen_US
dc.subjectClinicopathological Featuresen_US
dc.subjectPrimary Cutaneous Melanomaen_US
dc.subjectDabrafeniben_US
dc.subjectTrialen_US
dc.subjectMedicineen_US
dc.subjectFeaturesen_US
dc.subjectCanceren_US
dc.subjectTumorsen_US
dc.subjectNrasen_US
dc.titleBRAF V600 Mutation Profile of Metastatic Melanoma in the Thrace Region of Turkeyen_US
dc.typeArticleen_US

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