Hemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exercise

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dc.contributor.authorVardar, Selma Arzu
dc.contributor.authorPalabıyık, Orkide
dc.contributor.authorTopuz, Ruhan Deniz
dc.contributor.authorGürel, Elif Ezgi
dc.contributor.authorÇalışkan, Semra
dc.contributor.authorTopçu, Serap Özen
dc.contributor.authorSüt, Necdet
dc.date.accessioned2024-06-12T10:14:18Z
dc.date.available2024-06-12T10:14:18Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground/aim: Atrial natriuretic peptide (ANP) is known as a protective agent against ischemia-reperfusion injury for cardiomyocytes.We compared the hemodynamic efects of ANP and isatin, which is known as an ANP receptor blocker, in ischemia followed byreperfusion in exercised rat hearts with nonexercised ones.Materials and methods: Isolated hearts were perfused in 4 exercised (E) groups afer a running protocol for 5 days and 4 nonexercised(NE) groups. In the frst protocol, ANP was added to the perfusion solution before ischemia in an E and NE group. In the secondprotocol, diferent doses of isatin (0.1, 10, 100 µM/L) were added to the perfusion solution before ANP in 3 E and 3 NE groups. Lefventricular developed pressure (LVDP) and maximum and minimum rates of change in lef ventricular pressure (dP/dtmax and dP/dtmin) were recorded.Results: Higher LVDP and dP/dtmin values were observed in the E group than the NE group following addition of ANP before ischemia.Values of dP/dtmax were higher in the E group at the frst minute of reperfusion period. Hemodynamic diference was not observedbetween groups given the same amount of isatin before ANP.Conclusion: Tis study indicated that higher ANP concentrations before ischemia were more efective on the lef ventricle contractilityand relaxation functions in the hearts that were exposed to exercise.en_US
dc.identifier.endpage305en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.startpage298en_US
dc.identifier.trdizinid170933en_US]
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/170933
dc.identifier.urihttps://hdl.handle.net/20.500.14551/14567
dc.identifier.volume45en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleHemodynamic efects of atrial natriuretic peptide in ischemia-reperfusion injury that occurs afer exerciseen_US
dc.typeArticleen_US

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