The effect of platelet-rich plasma in inactive form on the burn zone of stasis in rats

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dc.authoridKaya, Oktay/0000-0001-9639-8022
dc.authoridGunduz, Ozgur/0000-0002-2470-3021
dc.authoridOrhan, Abdullah Erkan/0000-0001-6532-5840
dc.authorwosidGÜNDÜZ, Özgür/AAH-8717-2019
dc.authorwosidKaya, Oktay/JGL-9169-2023
dc.authorwosidGunduz, Ozgur/A-2351-2016
dc.authorwosidOrhan, Abdullah Erkan/A-6237-2017
dc.contributor.authorOrhan, Erkan
dc.contributor.authorSapmaz-Metin, Melike
dc.contributor.authorTarladacalisir-Topcu, Yeter
dc.contributor.authorGunduz, Ozgur
dc.contributor.authorKaya, Oktay
dc.date.accessioned2024-06-12T10:55:26Z
dc.date.available2024-06-12T10:55:26Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe protection of the burn stasis zone tissues (BSZT) reduces the width and depth of the burn injury. In this study, it is aimed to show the effect of platelet-rich plasma (PRP) on the burn zone of stasis. Seventy-two Wistar rats were used in the study. PRP was obtained from the blood taken from eight rats. The remaining 64 rats were divided into four groups. In Group 1, only the burn procedure was performed. In Group 2, 0.3 cc of physiological saline solution, in Group 3, 0.3 cc of platelet-poor plasma and in Group 4, 0.3 cc of PRP were intradermally injected into BSZT after burn procedure. 21.5% of the tissues in Group 1, 20.8% in Group 2, 27.0% in Group 3, and 69.6% in Group 4 were found to be alive. The autophagic cell number average was calculated as 340 in Group 1, 340 in Group 2, 335 in Group 3 and 450 in Group 4, while the average number of cells stained with Nrf2 was calculated as 225 in Group 1, 245 in Group 2, 250 in Group 3 and 370 in Group 4. When the groups were compared in terms of the living tissue ratio, autophagy and number of cells stained with Nrf2, the values in Group 4 were found to be statistically significantly higher compared to Group 1, Group 2 and Group 3, while there was no difference between Groups 1, 2 and 3. This study has shown that PRP has a protective effect on BSZT.en_US
dc.identifier.doi10.1080/2000656X.2019.1614454
dc.identifier.endpage308en_US
dc.identifier.issn2000-656X
dc.identifier.issn2000-6764
dc.identifier.issue5en_US
dc.identifier.pmid31082278en_US
dc.identifier.scopus2-s2.0-85065760683en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage301en_US
dc.identifier.urihttps://doi.org/10.1080/2000656X.2019.1614454
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19416
dc.identifier.volume53en_US
dc.identifier.wosWOS:000486121400008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofJournal Of Plastic Surgery And Hand Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBurnen_US
dc.subjectZone Of Stasisen_US
dc.subjectPlatelet Rich Plasmaen_US
dc.subjectRegenerationen_US
dc.subjectNecrosisen_US
dc.subjectFlapen_US
dc.titleThe effect of platelet-rich plasma in inactive form on the burn zone of stasis in ratsen_US
dc.typeArticleen_US

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