Identification of Patients with Microscopic Hematuria who are at Greater Risk for the Presence of Bladder Tumors Using a Dedicated Questionnaire and Point of Care Urine Test - A Study by the Members of Association of Urooncology, Turkey

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dc.authoridMangir, Naside/0000-0002-3062-6480
dc.authoridMangir, Naside/0000-0002-3062-6480
dc.authoridBozlu, Murat/0000-0002-8624-0149
dc.authorwosidMangir, Naside/P-3866-2018
dc.authorwosidMangir, Naside/H-8745-2019
dc.authorwosidKaplan, Mustafa/D-4977-2014
dc.authorwosidYildirim, Asif/N-5388-2019
dc.authorwosidTürkeri, Levent N./W-9283-2018
dc.authorwosidBozlu, Murat/O-5281-2017
dc.contributor.authorTurkeri, Levent
dc.contributor.authorMangir, Naside
dc.contributor.authorGunlusoy, Bulent
dc.contributor.authorYildirim, Asif
dc.contributor.authorBaltaci, Sumer
dc.contributor.authorKaplan, Mustafa
dc.contributor.authorBozlu, Murat
dc.date.accessioned2024-06-12T11:08:31Z
dc.date.available2024-06-12T11:08:31Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn patients with microscopic hematuria there is a need for better identification of those who are at greater risk of harbouring bladder tumors. The RisikoCheck (c) questionnaire has a strong correlation with the presence of urothelial carcinoma (UC) of the bladder and in combination with other available tests may help identify patients who require detailed clinical investigations due to increased risk of presence of bladder tumors. This study aimed to evaluate the efficacy of RisikoCheck (c) questionnaire together with NMP-22 (R) (BladderChek (R)) as a point-of-care urine test in predicting the presence of bladder tumors in patients presenting with microscopic hematuria as the sole finding. In this multi-institutional prospective evaluation of 303 consecutive patients without a history of urothelial carcinoma (UC), RisikoCheck (c) risk group assessment, urinary tract imaging and cystourethroscopy as well as urine cytology and Nuclear Matrix Protein-22 (NMP-22 BladderChek) testing were performed where available. The sensitivity, specificity, negative predictive value (NPV), and positive predictive values (PPV) for the risk adapted approach were calculated. All patients underwent cystoscopy, and tumors were detected in 18 (5.9%). Urine cytology and NMP-22 was positive for malignancy in 9 (3.2%) and 12 (7.5%) of patients, respectively. A total of 43 (14%) patients were in the high risk group according to the RisikoCheck (c) questionnaire. The sensitivity and specificity of the questionnaire in detecting a bladder tumor was 61.5 % and 84.0 % in the high risk group. In patients with either a positive NMP-22 test or high risk category RisikoCheck (c), 23.6% had bladder tumors with a corresponding sensitivity of 54.2% and specificity of 88.6%. If both tests were negative only 3.3% of the patients had bladder tumors. The results of our study suggest that the efficacy of diagnostic evaluation of patients with microscopic hematuria may be further enhanced by combining RisikoCheck (c) questionnaire with NMP-22.en_US
dc.identifier.doi10.7314/APJCP.2014.15.15.6283
dc.identifier.endpage6286en_US
dc.identifier.issn1513-7368
dc.identifier.issue15en_US
dc.identifier.pmid25124612en_US
dc.identifier.scopus2-s2.0-84906276693en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage6283en_US
dc.identifier.urihttps://doi.org/10.7314/APJCP.2014.15.15.6283
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22468
dc.identifier.volume15en_US
dc.identifier.wosWOS:000343723600055en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAsian Pacific Organization Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal Of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMicroscopic Hematuriaen_US
dc.subjectBladder Neoplasmsen_US
dc.subjectRisikocheck (C)en_US
dc.subjectNMP-22en_US
dc.subjectBladder Checken_US
dc.subjectCanceren_US
dc.subjectDiagnosisen_US
dc.subjectAdultsen_US
dc.subjectRecommendationsen_US
dc.subjectGuidelineen_US
dc.subjectAuaen_US
dc.titleIdentification of Patients with Microscopic Hematuria who are at Greater Risk for the Presence of Bladder Tumors Using a Dedicated Questionnaire and Point of Care Urine Test - A Study by the Members of Association of Urooncology, Turkeyen_US
dc.typeArticleen_US

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