L-Carnitine Ameliorates Glycerol-Induced Myoglobinuric Acute Renal Failure in Rats

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dc.authoridYALCIN, OMER TARIK/0000-0001-5626-1881
dc.authorwosidYALCIN, OMER TARIK/B-4744-2018
dc.contributor.authorUstundag, Sedat
dc.contributor.authorSen, Saniye
dc.contributor.authorYalcin, Omer
dc.contributor.authorCiftci, Senturk
dc.contributor.authorDemirkan, Bora
dc.contributor.authorTure, Mevlut
dc.date.accessioned2024-06-12T11:13:39Z
dc.date.available2024-06-12T11:13:39Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThere is increasing evidence indicating that oxidative stress plays an important role in the pathogenesis of rhabdomyolysis-induced myoglobinuric acute renal failure (ARF). During times of war and natural disasters, myoglobinuric ARF can assume epidemic proportions. Thus, early and effective renoprotective treatments are of utmost importance. It has been shown that L-carnitine, used as a safe and effective nutritional supplement for more than three decades, is effective in preventing renal injury in many renal injury models involving oxidative stress. The present study was performed to investigate the effects of L-carnitine in an experimental model of myoglobinuric ARF. Four groups of rats were employed in this study: group 1 served as a control; group 2 was given glycerol (10 mL/kg, i.m.); group 3 was given glycerol plus L-carnitine (100 mg/kg, i.p.), starting at the same time as the glycerol injection; group 4 was given glycerol plus L-carnitine (100 mg/kg, i.p.), starting 48h before the glycerol injection. After glycerol injections, the i.p. injections of L-carnitine were repeated every 24h for four days. Ninety-six hours after glycerol injections, blood samples and kidney tissues were taken from the anesthetized rats. Urea and creatinine levels in plasma, N-acetyl-beta-D-glucosaminidase activity in urine, and malondialdehyde levels and catalase enzyme activity in kidney tissue were determined. Histopathological changes and iron accumulation in the kidney tissue were evaluated. In this study, glycerol administration led to marked renal oxidative stress, as well as severe functional and morphological renal deterioration. L-carnitine, possibly via its antioxidant properties, ameliorates glycerol-induced myoglobinuric kidney injury.en_US
dc.description.sponsorshipTrakya University, Scientific Researchs Committee [TUBAP-448]en_US
dc.description.sponsorshipThis work was supported by Trakya University, Scientific Researchs Committee (project number TUBAP-448).en_US
dc.identifier.doi10.1080/08860220802599130
dc.identifier.endpage133en_US
dc.identifier.issn0886-022X
dc.identifier.issn1525-6049
dc.identifier.issue2en_US
dc.identifier.pmid19212909en_US
dc.identifier.scopus2-s2.0-61649089998en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage124en_US
dc.identifier.urihttps://doi.org/10.1080/08860220802599130
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23631
dc.identifier.volume31en_US
dc.identifier.wosWOS:000263289300007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofRenal Failureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRhabdomyolysisen_US
dc.subjectMyoglobinen_US
dc.subjectIronen_US
dc.subjectOxidative Stressen_US
dc.subjectAcute Renal Failureen_US
dc.subjectL-Carnitineen_US
dc.subjectFree-Radicalsen_US
dc.subjectNitric-Oxideen_US
dc.subjectRhabdomyolysisen_US
dc.subjectInjuryen_US
dc.subjectIronen_US
dc.subjectPharmacokineticsen_US
dc.subjectAntioxidanten_US
dc.subjectApoptosisen_US
dc.subjectHypoxiaen_US
dc.titleL-Carnitine Ameliorates Glycerol-Induced Myoglobinuric Acute Renal Failure in Ratsen_US
dc.typeArticleen_US

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