Potassium bromate-induced kidney damage in rats and the effect of gum acacia thereon

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridNemmar, Abderrahim/0000-0002-0699-1015
dc.authoridAl Za'abi, Mohammed/0000-0002-2019-1022
dc.authoridAshique, Mohammed/0000-0002-3132-1478
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidAl Za'abi, Mohammed/C-6591-2013
dc.contributor.authorAli, Badreldin H.
dc.contributor.authorAl Za'abi, Mohammed
dc.contributor.authorKaraca, Turan
dc.contributor.authorAl Suleimani, Yousuf
dc.contributor.authorAl Balushi, Khalid A.
dc.contributor.authorManoj, Priyadarsini
dc.contributor.authorAshique, Mohammed
dc.date.accessioned2024-06-12T11:12:41Z
dc.date.available2024-06-12T11:12:41Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPotassium bromate (KBrO3) is used in many countries in cosmetic and food industries. In this work, we investigated in male Sprague-Dawley rats, the effect of four graded oral doses of KBrO3 (5, 15, 45 and 135 mg/kg/day for 28 days) on renal function tests, inflammation, oxidative damage, and apoptosis, as well as on histopathology, using several traditional and novel renal injury biomarkers in plasma, urine and renal tissues. We also tested the possible ameliorative action of the renoprotective prebiotic agent gum acacia (GA) on the actions of KBrO3 when given concomitantly with it in the drinking water at a concentration of 15% w/v. Taken together, the results indicated that treatment with KBrO3 at the 45 and 135 mg/kg doses caused a significant dose-dependent nephrotoxicity, as evident by the measured renal structural and functional indices and biomarkers of toxicity. GA co-treatment significantly abated most of the indices and biomarkers of the renal toxicity caused by KBrO3, suggesting a beneficial effect and its possible inclusion in edible products where KBrO3 is still used.en_US
dc.description.sponsorshipSultan Qaboos University [IG/MED/PHAR/15/01]en_US
dc.description.sponsorshipThis work was supported by an internal grant from Sultan Qaboos University (IG/MED/PHAR/15/01). Thanks to Professor Gerald Blunden for reading the manuscript, and to the Sultan Qaboos University Animal House staff for looking after the animals used in this work.en_US
dc.identifier.endpage137en_US
dc.identifier.issn1943-8141
dc.identifier.issue1en_US
dc.identifier.pmid29422999en_US
dc.identifier.scopus2-s2.0-85041130086en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage126en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23270
dc.identifier.volume10en_US
dc.identifier.wosWOS:000425213900011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE-Century Publishing Corpen_US
dc.relation.ispartofAmerican Journal Of Translational Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPotassium Bromateen_US
dc.subjectKidneysen_US
dc.subjectGum Acaciaen_US
dc.subjectSprague-Dawley Ratsen_US
dc.subjectChronic-Renal-Failureen_US
dc.subjectInduced Nephrotoxicityen_US
dc.subjectInjury Biomarkersen_US
dc.subjectFischer-344 Ratsen_US
dc.subjectArabic Gumen_US
dc.subjectToxicityen_US
dc.subjectGenerationen_US
dc.subjectMechanismen_US
dc.subjectDiseaseen_US
dc.subjectEnzymesen_US
dc.titlePotassium bromate-induced kidney damage in rats and the effect of gum acacia thereonen_US
dc.typeArticleen_US

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