Effects of isoxsuprine hydrochloride on electrocardiographic and trace element status in sheeps
Küçük Resim Yok
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pakistan Medical Assoc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To study the effect of isoxsuprine hydrochloride on the ischaemic electrocardiographic change and trace element status in sheep. Methods: This study was conducted from March 16 to 23, 2012, at Istanbul University, Turkey, and comprised sheep aged 6 months. The animals were divided into two equal groups. The control group was fed a standard diet and had free access to water. In the experimental group, isoxsuprine hydrochloride was injected at a dose of 0.6 mg/kg through the intramuscular route. Electrocardiographic changes, including creatine kinase and cardiac troponin-I, and serum levels of selenium, copper, calcium, magnesium, iron and zinc were investigated in healthy sheep. SPSS 15 was used for statistical analysis. Results: The 14 sheep were divided into two groups of 7(50%) each. The overall mean weight of the study population was 35 +/- 10kg. Selenium, calcium, iron and zinc concentrations did not show any difference in serum samples (p > 0.05). However, copper and magnesium concentrations decreased in serum after the administration of the drug (p < 0.05). In the experimental group, ST segment depression and abnormal T-wave was found in 6(86%) animals within 60 min. Conclusion: Isoxsuprine hydrochloride increased cardiotoxicity risk in sheep.
Açıklama
Anahtar Kelimeler
Isoxsuprine Hydrochloride, Sheep, Cardiac Troponin-I, Ctni, Creatine Kinase-MB, CK-MB, Cardiac Troponin, Uterine, Relaxant, Ischemia, Drugs
Kaynak
Journal Of The Pakistan Medical Association
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
66
Sayı
8
