RELATIONSHIP OF MAGNESIUM LEVEL WITH GLYCEMIC CONTROL AND LIPID PROFILE IN ADULT PATIENTS WITH TYPE 1 DIABETES MELLITUS

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dc.authoridyılmaz bülbül, buket/0000-0003-2651-0036;
dc.authorwosidyılmaz bülbül, buket/JVZ-4676-2024
dc.authorwosidANDAÇ, BURAK/JEO-6641-2023
dc.contributor.authorAndac, Burak
dc.contributor.authorBulbul, Buket Yilmaz
dc.contributor.authorDurak, Dudu Merve
dc.contributor.authorCelik, Mehmet
dc.date.accessioned2024-06-12T11:16:49Z
dc.date.available2024-06-12T11:16:49Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractType 1 diabetes mellitus (T1 DM) is a disease caused by the autoimmune destruction of pancreatic beta cells due to environmental factors in individuals with genetic predisposition. Magnesium (Mg) is one of the environmental factors suggested to be effective in the pathogenesis and progression of T1 DM. While studies link Mg deficiency with poor glycemic control and dyslipidemia, there are also findings suggesting no association. We aimed to assess the serum Mg levels in adults with T1 DM and evaluate its relationship with glycemic control and lipid profile. The study included 95 type 1 diabetic patients, who presented at the Endocrinology outpatient clinic, and 95 age- and gender-matched individuals without chronic disease. The comparison between the study groups was made using Student's t-test for qualitative data analysis and Mann-Whitney U test for quantitative data analysis without normal distribution. The Mg level of the diabetic patients was significantly lower than in the control group (p<0.001). In diabetic patients, the Mg level was significantly higher in the group with Hba1c <7% compared to the group with HbA1c >= 7%. The patients were divided into two groups according to the optimal Mg cut-off value (0.8 mmol L-1) determined by ROC analysis. The median (interquartile range (IQR)) values of HbA1c were 8.9% (10) in patients with Mg levels <0.8 mmol L-1; 7.6% (6) in patients with Mg levels >= 0.8 mmol L-1 (p<0.001). Although some studies have shown that Mg deficiency is associated with higher levels of LDL-cholesterol, triglyceride, and lower levels of HDL-cholesterol, there was no significant difference in the lipid profile parameters in our study. When the cut-off value of Mg level was taken as 0.8 mmol L-1, we did not find a significant relationship between the Mg level and lipid profile parameters. We conclude that Mg levels were lower in patients with T1 DM, and it was associated with poor glycemic control. However, Mg levels were not associated with dyslipidemia. Maintaining the Mg level above 0.8 mmol L-1 should be a supportive approach for glycemic control; however, more prospective studies are needed on this topic.en_US
dc.identifier.doi10.5601/jelem.2021.26.1.2096
dc.identifier.endpage317en_US
dc.identifier.issn1644-2296
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85109178024en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage307en_US
dc.identifier.urihttps://doi.org/10.5601/jelem.2021.26.1.2096
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24471
dc.identifier.volume26en_US
dc.identifier.wosWOS:000659296300002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherPolish Society Magnesium Researchen_US
dc.relation.ispartofJournal Of Elementologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectType 1 Diabetes Mellitusen_US
dc.subjectAdultsen_US
dc.subjectMagnesiumen_US
dc.subjectLipid Profileen_US
dc.subjectSerum Magnesiumen_US
dc.subjectInsulin-Secretionen_US
dc.subjectDouble-Blinden_US
dc.subjectChildrenen_US
dc.subjectZincen_US
dc.subjectBlooden_US
dc.subjectAssociationen_US
dc.subjectAdolescentsen_US
dc.subjectExcretionen_US
dc.subjectChromiumen_US
dc.titleRELATIONSHIP OF MAGNESIUM LEVEL WITH GLYCEMIC CONTROL AND LIPID PROFILE IN ADULT PATIENTS WITH TYPE 1 DIABETES MELLITUSen_US
dc.typeArticleen_US

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