Increased adiponectin level in non-Hodgkin lymphoma and its relationship with interleukin-10. Correlation with clinical features and outcome

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dc.authorscopusid35546856700
dc.authorscopusid6701664192
dc.authorscopusid7004457653
dc.authorscopusid7003486028
dc.contributor.authorPamuk G.E.
dc.contributor.authorTurgut B.
dc.contributor.authorDemir M.
dc.contributor.authorVural Ö.
dc.date.accessioned2024-06-12T10:28:08Z
dc.date.available2024-06-12T10:28:08Z
dc.date.issued2006
dc.description.abstractIt was reported that interleukin-10 (IL-10) level increased in non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) patients; moreover this was associated with poor prognosis. In addition, it was stated that adiponectin induced the antiinflammatory cytokine IL-10. We evaluated adiponectin and IL-10 levels in NHL and CLL patients. We included newly diagnosed 28 NHL, 23 CLL patients, and 17 healthy subjects. In NHL patients, adiponectin level was higher than in CLL group and controls (p values <0.05). In CLL group, IL-10 level was lower than in NHL, and control groups (p values <0.05). Adiponectin level had a positive correlation with IL-10 level in the NHL patients (r=0.41, p=0.04). In the NHL group, the median survival of patients with high IL-10 levels was shorter (22 months vs. not reached, p=0.03). Increased IL-10 levels helped to predict poor outcome in our NHL patients. High adiponectin levels and a relationship between adiponectin/IL-10 in newly diagnosed NHL patients might suggest a role for both in the immunodysregulation in NHL.en_US
dc.identifier.endpage541en_US
dc.identifier.issn0392-9078
dc.identifier.issue4en_US
dc.identifier.pmid17310845en_US
dc.identifier.scopus2-s2.0-33846521088en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage537en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17091
dc.identifier.volume25en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofJournal of Experimental and Clinical Cancer Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdiponectin; Chronic Lymphocytic Leukemia; Clinical Features; Interleukin-10; Non-Hodgkin Lymphoma; Prognosisen_US
dc.subjectAdiponectin; Interleukin 10; Adult; Aged; Article; Cancer Survival; Chronic Lymphatic Leukemia; Clinical Feature; Controlled Study; Correlation Analysis; Female; Human; Immune Dysregulation; Major Clinical Study; Male; Nonhodgkin Lymphoma; Outcome Assessment; Prediction; Priority Journal; Prognosis; Protein Blood Level; Adiponectin; Aged; Chi-Square Distribution; Female; Humans; Interleukin-10; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Male; Middle Aged; Reference Valuesen_US
dc.titleIncreased adiponectin level in non-Hodgkin lymphoma and its relationship with interleukin-10. Correlation with clinical features and outcomeen_US
dc.typeArticleen_US

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