The Effect of Serum Magnesium Level on Stable Anticoagulation in Patients Using Warfarin for Various Cardiac Indications

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dc.authoridAkhan, Onur/0000-0003-4440-9599
dc.authoridArdahanli, Isa/0000-0002-9309-803X
dc.authoridCelik, Mehmet/0000-0001-7364-370X
dc.authorwosidAkhan, Onur/AEU-8033-2022
dc.authorwosidCelik, Mehmet/HKO-3681-2023
dc.contributor.authorArdahanli, Isa
dc.contributor.authorAkhan, Onur
dc.contributor.authorCelik, Mehmet
dc.date.accessioned2024-06-12T10:58:02Z
dc.date.available2024-06-12T10:58:02Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWarfarin is a vitamin K antagonist agent that inhibits clotting factors used for long-term anticoagulation. Time in therapeutic range (TTR) in patients using warfarin is one of the primary treatment effectiveness requirements. We aim to investigate the relationship between serum magnesium levels, the international normalized ratio (INR) values, and TTR values in people using warfarin for various indications. Our study is a single-center, cross-sectional, and retrospective study that included 169 patients between 18 and 70 who used warfarin for various indications. Demographic data, biochemical analysis, and coagulation parameters, including TTR calculation, were evaluated for all patients. Those with a TTR value below 60 were defined as labile INR, and those with 60 and above as stable INR group and compared. The mean INR value was higher in the labile INR group than the stable INR group (3.7 +/- 2.9, 3.2 +/- 0.3, respectively; p = 0.030). The Mg values are significantly lower in the labile INR group than the stable group (1.8 +/- 0.2 mg/dL, 2.0 +/- 0.1 mg/dL, respectively; p < 0.001). In binary multivariate logistic regression analysis, magnesium value was the most influential INR stabilization factor (p < 0.001). As a result of our study, it was concluded that magnesium levels are an influential factor in stabilizing INR. We can state that we have contributed to the literature and can be a reference for future studies.en_US
dc.identifier.doi10.1007/s12011-021-03036-y
dc.identifier.endpage4302en_US
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue10en_US
dc.identifier.pmid34981424en_US
dc.identifier.scopus2-s2.0-85122177913en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage4297en_US
dc.identifier.urihttps://doi.org/10.1007/s12011-021-03036-y
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19897
dc.identifier.volume200en_US
dc.identifier.wosWOS:000737735000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringernatureen_US
dc.relation.ispartofBiological Trace Element Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoagulationen_US
dc.subjectWarfarinen_US
dc.subjectMagnesiumen_US
dc.subjectProsthetic Valve Diseaseen_US
dc.subjectAtrial Fibrillationen_US
dc.subjectAtrial-Fibrillation Patientsen_US
dc.subjectTissue Factoren_US
dc.subjectSulfateen_US
dc.subjectRatioen_US
dc.subjectTimeen_US
dc.subjectRisken_US
dc.titleThe Effect of Serum Magnesium Level on Stable Anticoagulation in Patients Using Warfarin for Various Cardiac Indicationsen_US
dc.typeArticleen_US

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