Telomere length and hTERT in mania and subsequent remission

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dc.authorid, Rugül/0000-0003-2596-0473
dc.authorwosidçınar, rugül köse/S-8927-2019
dc.authorwosid, Rugül/AAI-1711-2019
dc.contributor.authorCinar, Rugul Kose
dc.date.accessioned2024-06-12T10:54:44Z
dc.date.available2024-06-12T10:54:44Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The findings of telomere length (TL) studies in bipolar disorder (BD) are controversial. The aim of the present study was to detect TL, human telomerase reverse transcriptase (hTERT), and brain derived neurotrophic factor (BDNF) in severe mania and subsequent remission. Methods: Twenty-one medication-free male patients and 20 age and gender matched controls were recruited. The patients were followed in the inpatient clinic, and comparisons were made between the same patients in their remission state and controls. Patients received lithium plus antipsychotics during the follow-up period. Quantitative real-time polymerase chain reaction was performed to verify leukocyte TL and whole blood hTERT gene expression levels. Serum BDNF levels were verified by enzyme-linked immunosorbent assay (ELISA). Results: Compared to controls, manic patients presented shorter telomeres (p < 0.001) whose length increased with treatment (p = 0.001). Patients in the late stages showed shorter TL than those in the early stages and controls (p < 0.001). hTERT gene expression levels were up-regulated in mania and remission compared to controls (p = 0.03 and p = 0.01, respectively). BDNF changes did not reach statistically significant levels. Conclusions: TL and hTERT gene expression might reflect a novel aspect of BD pathophysiology and TL might represent a novel biomarker for BD staging.en_US
dc.description.sponsorshipTrakya University Scientific Research Project Committee [TUBAP 2015/08]en_US
dc.description.sponsorshipThis study was supported by the Trakya University Scientific Research Project Committee (TUBAP 2015/08).en_US
dc.identifier.doi10.1590/1516-4446-2017-2216
dc.identifier.endpage25en_US
dc.identifier.issn1516-4446
dc.identifier.issn1809-452X
dc.identifier.issue1en_US
dc.identifier.pmid28700015en_US
dc.identifier.scopus2-s2.0-85044221046en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage19en_US
dc.identifier.urihttps://doi.org/10.1590/1516-4446-2017-2216
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19162
dc.identifier.volume40en_US
dc.identifier.wosWOS:000427922900004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Brasileira Psiquiatriaen_US
dc.relation.ispartofRevista Brasileira De Psiquiatriaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBipolar Disorderen_US
dc.subjectTelomereen_US
dc.subjectTERT Proteinen_US
dc.subjectBipolar Disorderen_US
dc.subjectPsychiatric-Disordersen_US
dc.subjectNeurotrophic Factoren_US
dc.subjectQuantitative Pcren_US
dc.subjectAllostatic Loaden_US
dc.subjectMetaanalysisen_US
dc.subjectDiseaseen_US
dc.subjectIllnessen_US
dc.subjectMechanismsen_US
dc.subjectNeuronsen_US
dc.titleTelomere length and hTERT in mania and subsequent remissionen_US
dc.typeArticleen_US

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