Immune Thrombotic Thrombocytopenic Purpura in Elderly Patients: The Roles of PLASMIC and French Scores

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dc.authoridAKPINAR, SEVAL/0000-0002-6961-8971
dc.authoridÖzlü, Can/0000-0002-9573-1177
dc.authoridBaysal, Mehmet/0000-0001-7681-4623
dc.authoridipek, yildiz/0000-0003-2952-2286
dc.authoridCiftciler, Rafiye/0000-0001-5687-8531
dc.authorwosidAKPINAR, SEVAL/HKD-9650-2023
dc.authorwosidKeklik, Fatma/IZQ-0529-2023
dc.authorwosidÖzlü, Can/JZS-8407-2024
dc.authorwosidBaysal, Mehmet/E-9111-2018
dc.authorwosidipek, yildiz/ACY-2160-2022
dc.contributor.authorBaysal, Mehmet
dc.contributor.authorHindilerden, Fehmi
dc.contributor.authorUmit, Elif Gulsum
dc.contributor.authorDemir, Ahmet Muzaffer
dc.contributor.authorKaradag, Fatma Keklik
dc.contributor.authorSaydam, Guray
dc.contributor.authorAkpinar, Seval
dc.date.accessioned2024-06-12T11:16:20Z
dc.date.available2024-06-12T11:16:20Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: In recent years, new developments have been incorporated into daily practice in the management of immune thrombotic thrombocytopenic purpura (iTTP). In particular, clinical scoring systems could help clinicians with clinical decision-making and early recognition. However, older patients frequently present with more organ involvement and in unusual ways. The ways in which age could affect these clinical prediction scoring systems remain unclear. We evaluated the use of PLASMIC and French scores in patients over 60 years of age. Materials and Methods: We performed a retrospective cross-sectional analysis of patients over 60 years of age with a presumptive diagnosis of iTTP between 2014 and 2022 at 10 centers. We calculated PLASMIC and French scores and compared our data with a single-center analysis of younger patients presenting with thrombotic microangiopathy. Results: Our study included 30 patients over 60 years of age and a control group of 28 patients younger than 60 years. The diagnostic sensitivity and specificity of a French score of >= 1 were lower in older patients compared to the control group (78.9% vs. 100% and 18.2% vs. 57.1%, respectively). The diagnostic sensitivity and specificity of a PLASMIC score of >= 5 were 100% vs. 95% and 27.3% vs. 100% for the study group and control group, respectively. Our study showed a higher mortality rate in older patients compared to the control group (30% vs. 7.1%, p=0.043). Conclusion: For a limited number of patients (n=6), our results showed that rituximab can reduce mortality. Given that the reliability of clinical prediction scores for iTTP in older patients may be lower, more caution must be undertaken in interpreting their results.en_US
dc.identifier.doi10.4274/tjh.galenos.2023.2023.0295
dc.identifier.endpage257en_US
dc.identifier.issn1300-7777
dc.identifier.issn1308-5263
dc.identifier.issue4en_US
dc.identifier.pmid37791641en_US
dc.identifier.scopus2-s2.0-85178658219en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage251en_US
dc.identifier.urihttps://doi.org/10.4274/tjh.galenos.2023.2023.0295
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24283
dc.identifier.volume40en_US
dc.identifier.wosWOS:001162684000003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofTurkish Journal Of Hematologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectThrombotic Thrombocytopenic Purpuraen_US
dc.subjectPLASMIC Scoreen_US
dc.subjectFrench Scoreen_US
dc.subjectElderlyen_US
dc.subjectAgeen_US
dc.subjectThrombotic Microangiopathyen_US
dc.subjectSevere Adamts13 Deficiencyen_US
dc.subjectValidationen_US
dc.subjectTtpen_US
dc.subjectMicroangiopathiesen_US
dc.subjectManagementen_US
dc.subjectDiagnosisen_US
dc.subjectConsensusen_US
dc.subjectOutcomesen_US
dc.subjectRegistryen_US
dc.subjectUtilityen_US
dc.titleImmune Thrombotic Thrombocytopenic Purpura in Elderly Patients: The Roles of PLASMIC and French Scoresen_US
dc.typeArticleen_US

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