The Effects of Hyperbaric Oxygen Treatment on Total Antioxidant Capacity and Prolidase Activity after Bile Duct Ligation in Rats

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dc.authoridGelisgen, Remise/0000-0003-4121-5107
dc.authoridAtukeren, Pinar/0000-0001-8219-4205
dc.authoridTeksöz, Duygu/0000-0002-4038-0795
dc.authoridUslu-Beşli, Lebriz/0000-0003-1868-3957
dc.authoridSimsek, Gonul/0000-0001-9403-4102
dc.authoridUzun, Hafize/0000-0002-1347-8498
dc.authorwosidGelisgen, Remise/D-2983-2019
dc.authorwosidAtukeren, Pinar/D-3163-2019
dc.authorwosidTeksöz, Duygu/GRY-4548-2022
dc.authorwosidşimşek, gönül/AAC-9310-2021
dc.authorwosidUslu-Beşli, Lebriz/A-5527-2019
dc.authorwosidSimsek, Gonul/D-4992-2019
dc.authorwosidUzun, Hafize/D-4811-2019
dc.contributor.authorTerzioglu, Duygu
dc.contributor.authorUslu, Lebriz
dc.contributor.authorSimsek, Gonul
dc.contributor.authorAtukeren, Pinar
dc.contributor.authorErman, Hayriye
dc.contributor.authorGelisgen, Remise
dc.contributor.authorAyvaz, Suleyman
dc.date.accessioned2024-06-12T11:07:45Z
dc.date.available2024-06-12T11:07:45Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Hyperbaric oxygen (HBO) therapy may improve cholestasis, increase hepatic regeneration, and decrease oxidative stress in liver. In this study, we aimed to investigate the effects of HBO therapy on hepatic oxidative stress parameters, such as total thiol groups (T-SH), protein carbonyl (PCO), and total antioxidant capacity (TAC) as well as the predictive value of the noninvasive biochemical marker, sialic acid (SA), and prolidase activity in bile duct ligation (BDL)-induced oxidative damage and fibrosis in rats. Methods: We divided 32 adult male Sprague Dawley rats into four groups: sham, sham + HBO, BDL, and BDL + HBO; each group contained eight animals. We placed the sham + HBO and BDL + HBO groups in an experimental hyperbaric chamber, in which we administered pure oxygen at 2.5 atmospheres for 90 min on 14 consecutive days. Results: The application of BDL significantly increased PCO levels and prolidase activity, and decreased T-SH and TAC levels. HBO significantly decreased PCO levels and prolidase activity and increased T-SH and TAC levels in the liver tissues. There was no significant difference in sialic acid levels between any groups. Conclusions: These results indicate that HBO therapy has hepatoprotective effects on BDL-induced injury by decreasing PCO and prolidase activity and increasing antioxidant activities. We therefore suggest that HBO therapy may be useful after BDL-induced injury.en_US
dc.identifier.doi10.1080/08941939.2016.1257666
dc.identifier.endpage382en_US
dc.identifier.issn0894-1939
dc.identifier.issn1521-0553
dc.identifier.issue6en_US
dc.identifier.pmid27922759en_US
dc.identifier.scopus2-s2.0-85002292018en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage376en_US
dc.identifier.urihttps://doi.org/10.1080/08941939.2016.1257666
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22172
dc.identifier.volume30en_US
dc.identifier.wosWOS:000416736600004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Investigative Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLiver Fibrosisen_US
dc.subjectHyperbaric Oxygen Therapyen_US
dc.subjectSialic Aciden_US
dc.subjectProtein Carbonyl Groupsen_US
dc.subjectProlidase Activityen_US
dc.subjectFerric-Reducing Antioxidant Poweren_US
dc.subjectChronic Liver-Diseaseen_US
dc.subjectSerum Prolidaseen_US
dc.subjectOxidative Stressen_US
dc.subjectSialic-Aciden_US
dc.subjectPlasma Prolidaseen_US
dc.subjectEnzyme-Activityen_US
dc.subjectCholestasisen_US
dc.subjectFibrosisen_US
dc.subjectDamageen_US
dc.subjectRegenerationen_US
dc.titleThe Effects of Hyperbaric Oxygen Treatment on Total Antioxidant Capacity and Prolidase Activity after Bile Duct Ligation in Ratsen_US
dc.typeArticleen_US

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