A case of cervical spine meningioma following etanercept use in a patient with RA

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dc.authorwosidHarmandar, Ferda/AAD-3862-2019
dc.contributor.authorPamuk, Oemer N.
dc.contributor.authorHarmandar, Ferda
dc.date.accessioned2024-06-12T11:19:28Z
dc.date.available2024-06-12T11:19:28Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground. a 70-year-old female with active rheumatoid arthritis (RA) was administered etanercept to treat active disease that persisted despite therapy with conventional DMARDs. after 18 months of etanercept therapy, her RA symptoms had improved; however, she developed quadriparesis. she presented to a specialist rheumatology clinic with weakness and numbness in her arms and legs; she also had difficulty in standing up and walking. Investigations. Physical examination, neurological examination, nerve conduction studies, measurement of serum inflammatory markers and autoantibodies, MRI of the cranium and cervical spine, and X-rays of the chest and hands. Diagnosis. the patient underwent neurosurgery to resect a 1 x 2 cm mass in the cervical spine at C6-C7. Histopathologic examination of the excised mass revealed it to be a meningioma. Management. etanercept was discontinued because of a possible association between the drug and development of meningioma; however, shortly afterwards the patient experienced a flare of RA symptoms. High-dose NSAIDs and prednisolone were administered, but the patient died because of gastric perforation. to our knowledge, this is the first report in the literature of meningioma developing following use of tumor necrosis factor inhibitor therapy, and the first to suggest a cause-effect relationship.en_US
dc.identifier.doi10.1038/nrrheum.2009.138
dc.identifier.endpage460en_US
dc.identifier.issn1759-4790
dc.identifier.issn1759-4804
dc.identifier.issue8en_US
dc.identifier.pmid19648944en_US
dc.identifier.scopus2-s2.0-73349131439en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage457en_US
dc.identifier.urihttps://doi.org/10.1038/nrrheum.2009.138
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25200
dc.identifier.volume5en_US
dc.identifier.wosWOS:000268536900010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofNature Reviews Rheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNecrosis Factor Therapyen_US
dc.subjectRheumatoid-Arthritisen_US
dc.subjectRisken_US
dc.subjectLymphomaen_US
dc.subjectMethotrexateen_US
dc.subjectMalignanciesen_US
dc.subjectMetaanalysisen_US
dc.titleA case of cervical spine meningioma following etanercept use in a patient with RAen_US
dc.typeArticleen_US

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