The role of curcumin on intestinal oxidative stress, cell proliferation and apoptosis after ischemia/reperfusion injury in rats

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dc.authorwosidGuzel, Ahmet/AGE-2880-2022
dc.contributor.authorYucel, Ahmet Fikret
dc.contributor.authorKanter, Mehmet
dc.contributor.authorPergel, Ahmet
dc.contributor.authorErboga, Mustafa
dc.contributor.authorGuzel, Ahmet
dc.date.accessioned2024-06-12T11:03:57Z
dc.date.available2024-06-12T11:03:57Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to demonstrate the role of curcumin on oxidative stress, cell proliferation and apoptosis in the rat intestinal mucosa after ischemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into three groups: sham, I/R and I/R? curcumin; each group contain 10 animals. Sham group animals underwent laparotomy without I/R injury. After I/R groups animals underwent laparotomy, 1 h of superior mesenteric artery ligation were followed by 1 h of reperfusion. In the curcumin group, 3 days before I/R, curcumin (100 mg/kg) was administered by gastric gavage. All animals were sacrificed at the end of reperfusion and intestinal tissues samples were obtained for biochemical and histopathological investigation in all groups. Curcumin treatment significantly decreased the elevated tissue malondialdehyde levels and increased of reduced superoxide dismutase, and glutathione peroxidase enzyme activities in intestinal tissues samples. I/R caused severe histopathological injury including mucosal erosions and villous congestion and hemorrhage. Curcumin treatment significantly attenuated the severity of intestinal I/R injury, with inhibiting of I/R-induced apoptosis and cell proliferation. These results suggest that curcumin treatment has a protective effect against intestinal damage induced by intestinal I/R. This protective effect is possibly due to its ability to inhibit I/R- induced oxidative stress, apoptosis and cell proliferation.en_US
dc.identifier.doi10.1007/s10735-011-9364-0
dc.identifier.endpage587en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue6en_US
dc.identifier.pmid21984066en_US
dc.identifier.scopus2-s2.0-81155148139en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage579en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-011-9364-0
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21856
dc.identifier.volume42en_US
dc.identifier.wosWOS:000300371400011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntestinal Ischemia/Reperfusionen_US
dc.subjectOxidative Stressen_US
dc.subjectProliferation And Apoptosisen_US
dc.subjectCurcuminen_US
dc.subjectRaten_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectMesenteric Ischemiaen_US
dc.subjectActivationen_US
dc.subjectInhibitionen_US
dc.subjectMucosaen_US
dc.subjectDeathen_US
dc.subjectSuperoxideen_US
dc.subjectPeroxidaseen_US
dc.subjectPreventionen_US
dc.subjectDiseaseen_US
dc.titleThe role of curcumin on intestinal oxidative stress, cell proliferation and apoptosis after ischemia/reperfusion injury in ratsen_US
dc.typeArticleen_US

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