Peripheral blood mRNA expressions of stress biomarkers in manic episode and subsequent remission

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dc.authorid, Rugül/0000-0003-2596-0473
dc.authoridGorgulu, Yasemin/0000-0002-3401-4879
dc.authorwosid, Rugül/AAI-1711-2019
dc.authorwosidçınar, rugül köse/S-8927-2019
dc.authorwosidGorgulu, Yasemin/S-4355-2017
dc.contributor.authorCinar, Rugul Kose
dc.contributor.authorSonmez, Mehmet Bulent
dc.contributor.authorGorgulu, Yasemin
dc.date.accessioned2024-06-12T10:54:42Z
dc.date.available2024-06-12T10:54:42Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractTheoretical models of the neuroprogressive nature of bipolar disorder (BD) are based on the hypothesis that it is an accelerated aging disease, with the allostatic load playing a major role. Glucocorticoids, oxidative stress markers, inflammatory cytokines and neurotrophins play important roles in BD. The messenger ribonucleic acid (mRNA) expressions of brain-derived neurotrophic factor (BDNF), tissue plasminogen activator (tPA), glucocorticoid receptor (GR), heat shock protein 70 (HSP70), tumour necrosis factor alpha (TNF-alpha) were examined in the peripheral blood of 20 adult male, drug-free BD patients during manic and remission periods and in 20 adult male, healthy controls. mRNA expression was measured using the quantitative real-time polymerase chain reaction (qRT-PCR). Compared to the controls, the expressions of BDNF and tPA mRNA were down-regulated in mania. In remission, BNDF and tPA mRNA levels increased, but they were still lower than those of the controls. Between mania and remission periods, only the change in mRNA levels of BDNF reached statistical significance. The results suggest that BDNF and tPA may be biomarkers of BD and that proteolytic conversion of BDNF may be important in the pathophysiology of BD. The change in BDNF levels between mania and remission could be adaptive and used to follow the progression of BD. (C) 2016 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipTrakya University Scientific Research Project Committee [TUBAP 2015/08]en_US
dc.description.sponsorshipThis study was funded by Trakya University Scientific Research Project Committee (TUBAP 2015/08). Funding sources had no role in collection or analysis of data, preparation of manuscript, or decision to submit manuscript.en_US
dc.identifier.doi10.1016/j.psyneuen.2016.04.020
dc.identifier.endpage16en_US
dc.identifier.issn0306-4530
dc.identifier.pmid27138695en_US
dc.identifier.scopus2-s2.0-84966454892en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage10en_US
dc.identifier.urihttps://doi.org/10.1016/j.psyneuen.2016.04.020
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19151
dc.identifier.volume70en_US
dc.identifier.wosWOS:000378965400002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofPsychoneuroendocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar Disorderen_US
dc.subjectBrain-Derived Neurotrophic Factoren_US
dc.subjectTissue Plasminogen Activatoren_US
dc.subjectGlucocorticoid Receptoren_US
dc.subjectHeat Shock Protein 70en_US
dc.subjectTumour Necrosis Factor-Alphaen_US
dc.subjectTissue-Plasminogen Activatoren_US
dc.subjectNeurotrophic Factor Bdnfen_US
dc.subjectBipolar Disorderen_US
dc.subjectInflammatory Markersen_US
dc.subjectEndothelial-Cellsen_US
dc.subjectMood Stabilizersen_US
dc.subjectOxidative Stressen_US
dc.subjectAntipsychoticsen_US
dc.subjectSchizophreniaen_US
dc.subjectResilienceen_US
dc.titlePeripheral blood mRNA expressions of stress biomarkers in manic episode and subsequent remissionen_US
dc.typeArticleen_US

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