Effect of preoperative oral use of erythromycin and nizatidine on gastric pH and volume

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dc.contributor.authorMemis, D
dc.contributor.authorTuran, A
dc.contributor.authorKaramanlioglu, B
dc.contributor.authorGuler, T
dc.contributor.authorYurdakoc, A
dc.contributor.authorPamukcu, Z
dc.contributor.authorTuran, N
dc.date.accessioned2024-06-12T11:12:32Z
dc.date.available2024-06-12T11:12:32Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThis randomized controlled trial examined the effects of preoperative oral erythromycin or nizatidine on gastric pH and volume. Sixty patients, ASA I and 2 status scheduled for elective surgery were studied. All subjects received oral study medication with 10 ml of water 60 minutes prior to surgery. Patients in Group I (it = 20) were given erythromycin 200 mg, in Group 2 (n = 20) nizatidine 300 mg, and in Group 3 (n = 20) placebo capsule. A nasogastric tube was inserted immediately after anaesthesia induction. Gastric content was aspirated, and volume and pH recorded. pH values determined in Group I were 5.6+/-1.87, in Group 2, 5.65+/-1.92 and in Group 3, 3.5+/-1.93. There was no statistical difference between Groups I and 2, but there was a statistically significant difference between Group 3 and Groups I and 2 (P<0.001). The volume of gastric content was 10.25+/-6.65 ml in Group 1, 10.3+/-6.29 ml in Group 2, and 20.25+/-16.72 ml in Group 3. Again, there was no statistical difference between Groups I and 2, but there was a statistically significant difference between Group 3 and Groups I and 2 (P<0.05). The proportion of patients considered at risk of significant lung injury should aspiration occur was 10% of Group 1, 5% of Group 2 and 20% of Group 3 (not statistically different). We conclude that oral erythromycin and nizatidine given one hour prior to surgery are effective in reducing gastric pH and volume.en_US
dc.identifier.doi10.1177/0310057X0203000404
dc.identifier.endpage432en_US
dc.identifier.issn0310-057X
dc.identifier.issn1448-0271
dc.identifier.issue4en_US
dc.identifier.pmid12180579en_US
dc.identifier.scopus2-s2.0-0036022979en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage428en_US
dc.identifier.urihttps://doi.org/10.1177/0310057X0203000404
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23192
dc.identifier.volume30en_US
dc.identifier.wosWOS:000177351800004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofAnaesthesia And Intensive Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPneumonia Aspiration : Preventionen_US
dc.subjectPreoperative Erythromycin, Nizatidineen_US
dc.subjectAcid Aspirationen_US
dc.subjectMotilinen_US
dc.titleEffect of preoperative oral use of erythromycin and nizatidine on gastric pH and volumeen_US
dc.typeArticleen_US

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