Investigation of insulin resistance gene polymorphisms in patients with differentiated thyroid cancer

Basit Öğe Kaydı
dc.authoridPalabıyık, Orkide/0000-0002-3488-3740
dc.authoridÇelik, Özlem/0000-0001-5149-8716;
dc.authorwosidPalabıyık, Orkide/Q-2792-2019
dc.authorwosidÇelik, Özlem/HPC-2361-2023
dc.authorwosidÇelik, Özlem/AAA-1326-2022
dc.authorwosidCELIK, OZLEM/A-5240-2018
dc.contributor.authorAkker, Mustafa
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorSipahi, Tammam
dc.contributor.authorPalabiyik, Orkide
dc.contributor.authorTosunoglu, Ayhan
dc.contributor.authorCelik, Ozlem
dc.contributor.authorTuncbilek, Nermin
dc.date.accessioned2024-06-12T10:59:37Z
dc.date.available2024-06-12T10:59:37Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe aimed to investigate insulin receptor substrate-1 (IRS-1), insulin receptor substrate-2 (IRS-2), insulin-like growth factor binding protein-3 (IGFBP-3) genotypes, which are thought to be involved in the pathogenesis of many solid tumors and have thus far not been studied in patients with differentiated thyroid cancer (DTC). The study consisted of 93 patients diagnosed with DTC (79 females, 14 males) and 111 healthy control subjects (63 females, 48 males). The anthropometric measurements, lipid profiles, thyroid function tests and homeostatic model assessment (HOMA) as an indicator of insulin resistance (IR) of all patients were recorded. In addition IRS-1, IRS-2 and IGFBP-3 gene polymorphisms were determined by using polymerase chain reaction and restriction fragment length polymorphism. Hardy-Weinberg equilibrium was tested for each gene polymorphisms, and genetic effects were evaluated by the Chi Square test and multiple logistic regression. Homeostasis model assessment of insulin resistance (HOMA-IR), body mass index, waist circumference and serum total cholesterol levels were significantly higher in patients with DTC than in the control group. There was no difference between the two groups with respect to IRS-1, IRS-2 and IGFBP-3 gene polymorphisms. In addition, these gene polymorphisms were found to have no effect on lymph node metastases or tumor staging. While, obesity and increased HOMA-IR may be risk factors in DTC development, we suggest that IRS-1, IRS-2 and IGFBP-3 gene polymorphisms do not play an important role in pathogenesis of DTC.en_US
dc.description.sponsorshipTrakya University [TUBAP-2011/35]en_US
dc.description.sponsorshipThe study was supported by the Research Fund of the Trakya University Scientific Research Project (TUBAP-2011/35).en_US
dc.identifier.doi10.1007/s11033-014-3218-2
dc.identifier.endpage3547en_US
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue5en_US
dc.identifier.pmid24504452en_US
dc.identifier.scopus2-s2.0-84905675898en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3541en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-014-3218-2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20495
dc.identifier.volume41en_US
dc.identifier.wosWOS:000335734400088en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDifferentiated Thyroid Canceren_US
dc.subjectInsulin Resistanceen_US
dc.subjectIRS-1en_US
dc.subjectIRS-2 And IGFBP-3 Gene Polymorphismsen_US
dc.subjectIGFBP-3 Gene Polymorphismsen_US
dc.subjectIgf-Binding Protein-3en_US
dc.subjectBody-Mass Indexen_US
dc.subjectGrowth-Factor-Ien_US
dc.subjectPooled Analysisen_US
dc.subjectProstate-Canceren_US
dc.subjectEndometrial Canceren_US
dc.subjectRisk Evidenceen_US
dc.subjectSerum-Levelsen_US
dc.subjectCarcinomaen_US
dc.subjectObesityen_US
dc.titleInvestigation of insulin resistance gene polymorphisms in patients with differentiated thyroid canceren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu