Spinal cord injury
Küçük Resim Yok
Tarih
2006
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Traumatic injury to the spinal cord typically results in axonal damage and cell death and leaves individuals with varying degrees of functional impairments. Damage arising from acute Spinal Cord Injury is generally described as two distinct pathophysiological events. The damage incurred at the time of injury is termed primary injury and typically results from direct mechanical disruption of cord integrity. Secondary injury occurs in a delayed yet progressive fashion and involves cellular and biochemical events that initiate cascades culminating in tissue damage and cell death. Secondary injury spreads away from the injury epicenter, incorporating tissue both rostral and caudal to the primary lesion with increasing functional deficits. The pathophysiological events contributing to secondary injury are thought to involve free radical production, lipid peroxidation, eicosanoid and prostaglandin production, protease activity, excitotoxic molecules such as glutamate, and intracellular increases in Ca2+. Neuroprotective strategies aimed at preventing damage arising from secondary injury processes provide some hope for tissue sparing and improved functional outcome. To date, methylprednisolone is the only drug currently approved for use in the treatment of acute Spinal Cord Injury. However, the use of high-dose methylprednisolone in acute Spinal Cord Injury has become largely risk and serious adverse effects, in This conjunction with the fact that current treatment options are need to find novel therapeutic agents. In this article, pathophysiologia and effect on therapy of secondary celluler injury after spinal cord injury have been reviewed.
Açıklama
Anahtar Kelimeler
Dizocilpine; Ganglioside Gm1; Icosanoid; Methylprednisolone; N Methyl Dextro Aspartic Acid Receptor; Prostaglandin; Proteinase; Axonal Injury; Cell Death; Clinical Trial; Enzyme Activity; Human; Lipid Peroxidation; Review; Risk Factor; Spinal Cord Injury; Tissue Injury
Kaynak
SENDROM
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
18
Sayı
12
