Effect of aminophylline in patients with atropine-resistant late advanced atrioventricular block during acute inferior myocardial infarction

dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorAltun, A
dc.contributor.authorKirdar, C
dc.contributor.authorOzbay, G
dc.date.accessioned2024-06-12T10:51:25Z
dc.date.available2024-06-12T10:51:25Z
dc.date.issued1998
dc.departmentTrakya Üniversitesien_US
dc.description1st International Congress on Coronary Artery Disease - from Prevention to Intervention -- SEP, 1997 -- PRAGUE, CZECH REPUBLICen_US
dc.description.abstractBackground: Advanced atrioventricular (AV) block is a frequent complication in patients with acute inferior myocardial infarction (AIMI). This conduction abnormality is associated with narrow QRS complex in conducted or junctional escape beats, suggesting that the site of block is the AV node; however, its pathophysiology has not been properly established. Hypothesis: This study investigated the effect of aminophylline in eight patients (5 men, 3 women, age range 51 to 78 years, mean 67.5 +/- 8.8 years) with atropine-resistant late advanced AV block during AIMI. Methods: Advanced AV block was late in appearance in all patients, starting 2 to 5 days after AIMI, and consisted of second-degree Mobitz II type in two patients and of complete AV block in six patients; all patients had narrow QRS complexes. Before aminophylline administration, all patients had a temporary pacemaker installed which was switched off throughout the study. They were given intravenous atropine (1 mg) that was found to be ineffective. One-half h after atropine, the first aminophylline injection (240 mg) was given intravenously over 10 min. One h following the first injection, a second aminophylline dose (240 mg) was administered. Electrocardiographic rhythm strips were obtained before and after drug administration, and the type of AV block and atrial and ventricular rate were noted. Results: Aminophylline restored 1:1 conduction with first-degree AV block in six patients, Mobitz I AV block in one patient, and normal sinus rhythm in one patient. Mean atrial and ventricular rates before aminophylline were 104 +/- 16 beats/min and 57 +/- 9 beats/min, respectively, and after drug administration 95 +/- 25 beats/min and 89 +/- 17 beats/min, respectively, (p = 0.012). Conclusion: These results indicate that aminophylline improves AV conduction in atropine-resistant late advanced AV block complicating AIMI.en_US
dc.identifier.endpage762en_US
dc.identifier.issn0160-9289
dc.identifier.issue10en_US
dc.identifier.pmid9789698en_US
dc.identifier.scopus2-s2.0-0031719044en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage759en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18364
dc.identifier.volume21en_US
dc.identifier.wosWOS:000076218800011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherClinical Cardiology Publ Coen_US
dc.relation.ispartofClinical Cardiologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAminophyllineen_US
dc.subjectAdvanced Atrioventricular Blocken_US
dc.subjectInferior Myocardial Infarctionen_US
dc.subjectPrognostic-Significanceen_US
dc.subjectAdenosineen_US
dc.subjectConductionen_US
dc.subjectTermen_US
dc.titleEffect of aminophylline in patients with atropine-resistant late advanced atrioventricular block during acute inferior myocardial infarctionen_US
dc.typeConference Objecten_US

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