The protective effects of Ginkgo biloba EGb761 extract against renal ischemia-reperfusion injury in rats

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dc.contributor.authorAkdere, H.
dc.contributor.authorTastekin, E.
dc.contributor.authorMericliler, M.
dc.contributor.authorBurgazli, K. M.
dc.date.accessioned2024-06-12T11:13:36Z
dc.date.available2024-06-12T11:13:36Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: The aim of the study was to investigate the protective effects of Ginkgo biloba EGb761 extract on renal ischemia-reperfusion (I/R) injury in rats. MATERIALS AND METHODS: 26 male Wistar albino rats were divided into four groups: First group (n=6), which served as control received only standard pellet; second group (IR) (n=6) was subjected to renal I/R injury; a third group (Gb) (n=7) was given additional EGb761 extract; and rats in the fourth group (IR-Gb) (n=7) had been treated with EGb761 extract before they were subjected to I/R injury. After rats were euthanized, renal tissues were analyzed microscopically, and tissue malondyaldehyde (MDA), catalase (CAT), and superoxide dismutase (SOD) levels were determined. RESULTS: MDA values were significantly high in the IR group when compared with the other groups. No significant difference in MDA values between the Control and Gb groups was observed. SOD enzyme activity was significantly lower in the IR group when compared with other groups. Furthermore, SOD values were found to be comparable in control, Gb and IR-Gb groups. The CAT enzymatic activity was significantly low in the IR group when compared with the other groups. Moreover, although no statistical significance was identified between control group and Gb group, CAT levels in these groups were higher compared to IR-Gb group. Microscopic examination showed no histopathological differences between the control and Gb groups. Cast formation and tubular necrosis in the IR group have been determined to be significantly high when compared with IR-Gb group. We further observed that the histopathological changes in the IR-Gb group were lesser in the advanced levels when compared with the IR group. CONCLUSIONS: Ginkgo biloba Egb761 extract applied before renal ischemia-reperfusion decreases the tissue damage.en_US
dc.identifier.endpage2941en_US
dc.identifier.issn1128-3602
dc.identifier.issue19en_US
dc.identifier.pmid25339489en_US
dc.identifier.scopus2-s2.0-84941059226en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2936en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23590
dc.identifier.volume18en_US
dc.identifier.wosWOS:000352209800022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRenal Ischemia/Reperfusionen_US
dc.subjectInjuryen_US
dc.subjectGinkgo Bilobaen_US
dc.subjectEgb7en_US
dc.subjectMelatoninen_US
dc.titleThe protective effects of Ginkgo biloba EGb761 extract against renal ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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