Serum osteoprotegerin levels in patients with acute atherothrombotic stroke and lacunar infarct

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dc.authoridGULDIKEN, Baburhan/0000-0002-9006-1880
dc.authorwosidTurgut, Burhan/A-2517-2016
dc.contributor.authorGuldiken, Baburhan
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorTurgut, Burhan
dc.contributor.authorTurgut, Nilda
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorCelik, Yahya
dc.contributor.authorArikan, Ender
dc.date.accessioned2024-06-12T11:07:18Z
dc.date.available2024-06-12T11:07:18Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Arterial calcification is associated with increased risk of cardiovascular events. Osteoprotegerin (OPG) is a cytokine involved in the bone metabolism and vascular calcification. Recent data support a relationship between high serum levels of OPG and increased risk for cardiovascular disease in human. The aim of this study was to evaluate the OPG serum levels in acute ischemic stroke. Our study was further designed to detect differences in serum OPG levels between subtypes of ischemic stroke. Materials and methods: The study consisted of 51,patients with acute ischemic stroke and 28 control subjects. Stroke subtypes were defined by the TOAST classifications. Serum OPG levels were measured with the ELISA method. Results: OPG serum levels were significantly higher in patients with ischemic stroke than in control subjects (p < 0.001). OPG serum levels were significantly higher in large-vessel disease (LVD) subtype compared with small-vessel disease (SVD) subtype and controls (p < 0.001, p < 0.001). There was no significant difference in OPG serum levels between SVD group and control subjects. Serum OPG levels were correlated with age (r=0.407, p=0:005) and fasting glucose levels (r=0.542, p=0:001) in ischemic stroke group. Logistic regression analysis showed that plasma OPG levels (OR 2.1, 95% CI, 1.16 to 3.4, p=0.01) associated with presence of stroke independently of the other risk factors. Conclusions: High serum OPG levels were associated with the WD stroke subtype, suggesting that OPG levels may play role in pathogenesis of atherothrombotic stroke. The precise mechanism for the role of OPG in atherosclerosis needs to be investigated further. (c) 2006 Elsevier Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.thromres.2006.12.004
dc.identifier.endpage516en_US
dc.identifier.issn0049-3848
dc.identifier.issue4en_US
dc.identifier.pmid17258300en_US
dc.identifier.scopus2-s2.0-34447650617en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage511en_US
dc.identifier.urihttps://doi.org/10.1016/j.thromres.2006.12.004
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21985
dc.identifier.volume120en_US
dc.identifier.wosWOS:000249170400009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofThrombosis Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIschemic Strokeen_US
dc.subjectOsteoprotegerinen_US
dc.subjectAtherosclerosisen_US
dc.subjectSmall-Vessel Diseaseen_US
dc.subjectLarge-Vessel Diseaseen_US
dc.subjectLacgnar Infarcten_US
dc.subjectCoronary-Artery-Diseaseen_US
dc.subjectIschemic-Strokeen_US
dc.subjectLiganden_US
dc.subjectAgeen_US
dc.subjectAtherosclerosisen_US
dc.subjectCalcificationen_US
dc.subjectMechanismsen_US
dc.subjectSeverityen_US
dc.subjectReceptoren_US
dc.subjectDensityen_US
dc.titleSerum osteoprotegerin levels in patients with acute atherothrombotic stroke and lacunar infarcten_US
dc.typeArticleen_US

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