Increased mitochondrial and cytosolic antioxidant enzymes in manic episodes

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dc.authoridGorgulu, Yasemin/0000-0002-3401-4879
dc.authorwosidGorgulu, Yasemin/S-4355-2017
dc.contributor.authorKilic, E. Kahyaci
dc.contributor.authorCinar, R. Kose
dc.contributor.authorGorgulu, Y.
dc.contributor.authorSonmez, M. B.
dc.date.accessioned2024-06-12T10:54:43Z
dc.date.available2024-06-12T10:54:43Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and objectives: An increasing number of studies have been conducted to investigate the role of oxidative stress in the pathophysiology of bipolar disorder (BD). The aim of our study was to detect the levels of plasma malondialdehyde and the gene expression of antioxidant enzymes in BD patients during manic period and to assess the changes of these markers during the subsequent remission period. Methods: This study involved 20 drug-free, hospitalized patients with BD type I who met the manic episode diagnostic criteria according to DSM-5, as well as 20 age-sex matched healthy controls. As a marker of lipid damage, malondialdehyde plasma levels were measured by the thiobarbituric acid method; mRNA expression levels of catalase (CAT), glutathione peroxidase (GPx), glutathione synthetase (GS), superoxide dismutase (SOD1) and mitochondrial superoxide dismutase (SOD2) were measured by real-time quantitative PCR from peripheral whole blood samples. Results: In a manic episode, the expression levels of CAT, GPx, GS and SOD2 were higher in the patients than the healthy controls. With treatment, only the GPx levels decreased significantly. The malondialdehyde and SOD1 levels did not differ between the patients and controls, and in the patient group, they did not differ between the mania and remission periods. Conclusion: This is the first study that has assessed the mRNA expression levels of antioxidant enzymes in patients with BD type I. The data from this study suggests that there is an increase in the expression of antioxidant enzymes as a response to oxidative stress in BD, and that the gene expression levels of these antioxidant enzymes could be potential biomarkers for manic phase of the disorder. (C) 2020 Asociacion Universitaria de Zaragoza para el Progreso de la Psiquiatria y la Salud Mental. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.description.sponsorshipScientific Research Projects Unit of the Trakya University, Edirne, Turkey [2014/100]en_US
dc.description.sponsorshipThis study was supported by grant form the Scientific Research Projects Unit of the Trakya University, Edirne, Turkey (Project No.: 2014/100).en_US
dc.identifier.doi10.1016/j.ejpsy.2020.08.001
dc.identifier.endpage188en_US
dc.identifier.issn0213-6163
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85091688953en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage181en_US
dc.identifier.urihttps://doi.org/10.1016/j.ejpsy.2020.08.001
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19160
dc.identifier.volume34en_US
dc.identifier.wosWOS:000576605100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Espana Sluen_US
dc.relation.ispartofEuropean Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar Disorderen_US
dc.subjectOxidative Stressen_US
dc.subjectMatandialdehydeen_US
dc.subjectAntioxidant Enzymesen_US
dc.subjectGene Expressionen_US
dc.subjectIncreased Oxidative Stressen_US
dc.subjectPostmortem Prefrontal Cortexen_US
dc.subjectAcid Reactive Substancesen_US
dc.subjectN-Acetyl Cysteineen_US
dc.subjectBipolar Disorderen_US
dc.subjectSuperoxide-Dismutaseen_US
dc.subjectNitric-Oxideen_US
dc.subjectDna-Damageen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectAnimal-Modelen_US
dc.titleIncreased mitochondrial and cytosolic antioxidant enzymes in manic episodesen_US
dc.typeArticleen_US

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