Un-methylation of the survivin gene has no effect on immunohistochemical expression of survivin protein in lung cancer patients with squamous cell carcinoma

Basit Öğe Kaydı
dc.authoridYALCIN, OMER TARIK/0000-0001-5626-1881
dc.authoridbudak, metin/0000-0002-5968-2048
dc.authorwosidYALCIN, OMER TARIK/B-4744-2018
dc.authorwosidBudak, metin/Z-3010-2019
dc.contributor.authorYalcin, O.
dc.contributor.authorBudak, M.
dc.date.accessioned2024-06-12T11:15:54Z
dc.date.available2024-06-12T11:15:54Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSurvivin is a member of the inhibitor of apoptosis (IAP) family. The function of the survivin protein is to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by the disruption of survivin induction pathways leading to an increased apoptosis and decreased tumour growth. These data suggest that survivin may provide a new target for cancer treatment, which would distinguish transformed cells from normal cells. In the present study, we aimed to investigate exon 1 of the survivin gene by means of methylation-specific PCR and evaluate its impact on survivin protein expression following DNA isolation and bisulphite modification in paraffin-embedded normal and tumour tissues of lung cancer patients with squamous cell carcinoma. We used 41 squamous cancer tissues with methylation in exon 1 of the survivin gene and non-methylation in corresponding tumours. However, the immunohistochemistry staining of these samples demonstrated an increased survivin protein compared to normal tissue. While there is almost no other study to date on this subject matter, we believe that the absence of methylation in exon 1 of the survivin gene may not affect disease prognosis as it has no effect on expression, and possible promoter methylation or transcription factors (Tab. 1, Fig. 4, Ref. 15). Text in PDF www.elis.sk.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey TUBITAK [3501-113S158]en_US
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey TUBITAK under the Grant Project no: 3501-113S158.en_US
dc.identifier.doi10.4149/BLL_2017_032
dc.identifier.endpage163en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue3en_US
dc.identifier.pmid28319412en_US
dc.identifier.scopus2-s2.0-85015691622en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage160en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2017_032
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24109
dc.identifier.volume118en_US
dc.identifier.wosWOS:000398005800007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSurvivinen_US
dc.subjectMethylationen_US
dc.subjectLung Canceren_US
dc.subjectMethylationen_US
dc.subjectSurvivin Geneen_US
dc.subjectSquamous Cell Carcinomaen_US
dc.subjectIncenpen_US
dc.titleUn-methylation of the survivin gene has no effect on immunohistochemical expression of survivin protein in lung cancer patients with squamous cell carcinomaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu