Chronic Water-Pipe Smoke Exposure Induces Injurious Effects to Reproductive Systemin Male Mice

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dc.authoridShalaby, Asem Ali Esmaeil/0000-0001-8032-2306
dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authoridAdham, Sirin/0000-0002-8349-6202
dc.authoridYUVARAJU, PRIYADHARSHINI/0000-0003-2383-457X
dc.authoridAshique, Mohammed/0000-0002-3132-1478
dc.authoridShalaby, Asem/0000-0002-7400-3373
dc.authoridNemmar, Abderrahim/0000-0002-0699-1015
dc.authorwosidShalaby, Asem Ali Esmaeil/Y-8321-2019
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.authorwosidAdham, Sirin/ABB-8842-2020
dc.authorwosidShalaby, Asem/A-1158-2019
dc.contributor.authorAli, Badreldin H.
dc.contributor.authorAl Balushi, Khalid A.
dc.contributor.authorAshique, Mohammed
dc.contributor.authorShalaby, Asem
dc.contributor.authorAl Kindi, Mohammed A.
dc.contributor.authorAdham, Sirin A.
dc.contributor.authorKaraca, Turan
dc.date.accessioned2024-06-12T11:17:14Z
dc.date.available2024-06-12T11:17:14Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThere is a global increase in the popularity of water-pipe tobacco smoking including in Europe and North America. Nevertheless, little is known about the male reproductive effects of water-pipe smoke (WPS), especially after long-term exposure. Here, we assessed effects of WPS exposure (30min/day) in male mice for 6 months. Control mice were exposed to air-only for the same period of time. Twenty-four hours after the last exposure, testicular histopathology, and markers of inflammation and oxidative stress, and the tyrosine-protein kinase vascular endothelial growth factor receptor 1 (VEGFR1) were assessed in testicular homogenates. Moreover, plasma testosterone, estradiol, and luteinizing hormone (LH) concentrations were also measured. Chronic WPS exposure induced a significant decrease of testosterone and estradiol, and a slight but significant increase of LH. Glutathione reductase, catalase, and ascorbic acid were significantly decreased following WPS exposure. Plasma concentration of leptin was significantly decreased by WPS exposure, whereas that of tumor necrosis factor a and interleukin 6 was significantly increased. Histopathological analysis of the testes revealed the presence of a marked reduction in the diameter of the seminiferous tubules with reduced spermatogenesis. Transmission electron microscopy examination showed irregular thickening and wrinkling of the basement membranes with abnormal shapes and structures of the spermatozoa. VEGFR1 was overexpressed in the testis of the mice exposed to WPS and was not detected in the control. The urine concentration of cotinine, the predominant metabolite of nicotine, was significantly increased in the WPS-exposed group compared with the control group. We conclude that chronic exposure to WPS induces damaging effects to the reproductive system in male mice. If this can be confirmed in humans, it would be an additional concern to an already serious public health problem, especially with the increased use ofWPS use all over the world, especially in young adults.en_US
dc.description.sponsorshipSultan Qaboos University [IG/MED/DEAN/15/1]; United Arab Emirate University [31M189, 31R052]en_US
dc.description.sponsorshipThis work was supported by Sultan Qaboos University (IG/MED/DEAN/15/1, in Oman) and the United Arab Emirate University [CMHS, UPAR (31M189) and Center-based interdisciplinary (31R052) grants, in the United Arab Emirates].en_US
dc.identifier.doi10.3389/fphys.2017.00158
dc.identifier.issn1664-042X
dc.identifier.pmid28420996en_US
dc.identifier.scopus2-s2.0-85018396849en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fphys.2017.00158
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24621
dc.identifier.volume8en_US
dc.identifier.wosWOS:000398635600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectWater-Pipe Smokeen_US
dc.subjectMiceen_US
dc.subjectTobaccoen_US
dc.subjectTestesen_US
dc.subjectReproductive Hormonesen_US
dc.subjectOxidative Stressen_US
dc.subjectCigarette-Smokingen_US
dc.subjectNarghile Smokingen_US
dc.subjectShisha Smokingen_US
dc.subjectNoseen_US
dc.subjectRatsen_US
dc.subjectTestisen_US
dc.subjectDamageen_US
dc.subjectInflammationen_US
dc.subjectDysfunctionen_US
dc.titleChronic Water-Pipe Smoke Exposure Induces Injurious Effects to Reproductive Systemin Male Miceen_US
dc.typeArticleen_US

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