A pH-Sensitive Chitosan/Oxidized-Kappa-Carrageenan based Nano-Antibiotic for Sustained and Controlled Release of Amoxicillin

Basit Öğe Kaydı
dc.authoridYİLMAZ, HABİBE/0000-0003-1106-0458
dc.authorwosidYİLMAZ, HABİBE/AAG-5274-2019
dc.contributor.authorYilmaz, Habibe
dc.date.accessioned2024-06-12T10:51:27Z
dc.date.available2024-06-12T10:51:27Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractNowadays antibiotic resistance is one of the most serious problems. Therefore, there is a need for sustained and controlled drug release systems for antibiotics. The aim of this study was to develop a nano-antibiotic system using biocompatible and antimicrobial polymers that are abundant in nature. Frequently used amoxicillin was chosen as the antibiotic. Before nanoparticle synthesis kappa-carrageenan was oxidized and 1.2% carboxyl, and 23.08% aldehyde groups were obtained, as confirmed by Fourier-transform infrared spectroscopy. A combination of polyelectrolyte complexation and ionic gelation was occurred in the nanoparticle synthesis. For the optimal temperature, CaCl2 concentration and polymer ratio of 37 degrees C, 1.5% and 6:1, respectively, the results of hydrodynamic size measurements indicated the size was 414.4 nm. Drug loading encapsulation was successful with an efficiency of 73.28%. Drug release was monitored for 95 h, and drug release was 93% and 85%, respectively, at pH 6.0 and pH 7.4. It is shown by the mathematical models that the drug release profile can be explained by the Higuchi and first-order models since R-2 values were higher than for the other models. As a result, it was observed that the obtained nano-antibiotic delivery system performed a long-term drug release of approximately 4 days in a pH-sensitive manner and would be a promising drug delivery system.en_US
dc.identifier.doi10.1080/00222348.2022.2119328
dc.identifier.endpage941en_US
dc.identifier.issn0022-2348
dc.identifier.issn1525-609X
dc.identifier.issue7-8en_US
dc.identifier.scopus2-s2.0-85138301014en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage926en_US
dc.identifier.urihttps://doi.org/10.1080/00222348.2022.2119328
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18373
dc.identifier.volume61en_US
dc.identifier.wosWOS:000851613200001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofJournal Of Macromolecular Science Part B-Physicsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAmoxicillinen_US
dc.subjectChitosanen_US
dc.subjectDrug Deliveryen_US
dc.subjectOxidized Kappa-Carrageenanen_US
dc.subjectPolymeric Nanoparticleen_US
dc.subjectChitosan/Carrageenan Nanoparticlesen_US
dc.subjectThermoreversible Gelationen_US
dc.titleA pH-Sensitive Chitosan/Oxidized-Kappa-Carrageenan based Nano-Antibiotic for Sustained and Controlled Release of Amoxicillinen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu