The evaluation of the distribution of CD133, CXCR1 and the tumor associated macrophages in different molecular subtypes of breast cancer

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dc.authoridKorkmaz, Selçuk/0000-0003-4632-6850
dc.authoridMuftuoglu, Sevda/0000-0003-0664-0204
dc.authoridILGIN, CAN/0000-0003-1751-8546
dc.authorwosidKorkmaz, Selçuk/AAU-4677-2020
dc.authorwosidvardar, enver/AAB-1508-2020
dc.authorwosidComut, Erdem/IZP-6524-2023
dc.authorwosidMuftuoglu, Sevda/AAA-6240-2021
dc.contributor.authorIlgin, Can
dc.contributor.authorComut, Erdem
dc.contributor.authorSarigul, Caglar
dc.contributor.authorKorkmaz, Selcuk
dc.contributor.authorVardar, Enver
dc.contributor.authorMuftuoglu, Sevda Fatma
dc.date.accessioned2024-06-12T10:55:16Z
dc.date.available2024-06-12T10:55:16Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description15th International Congress of Histochemistry and Cytochemistry (ICHC) - From Molecules to Diseases -- MAY 18-21, 2017 -- Antalya, TURKEYen_US
dc.description.abstractBreast cancer has different molecular subtypes, which determine the prognosis and response to the treatment. CD133 is a marker for cancer stem cells in tumor microenvironment with diagnostic/therapeutic importance. The tumor associated macrophages (TAMs) interact with the cancer stem cells through the CXCR1 receptor. In this study, we wanted to investigate the expression of these markers in patients with different molecular subtypes, in order to detect pathophysiological mechanisms and new molecular targets for the prospective targeted therapies. In this study we hypothesized a difference in expression of these antigens among different subtypes. We investigated expression of antigens in breast cancer patients with luminal A (LA), luminal B (LB), HER2 overexpressing (HER2OE), triple negative (TN) subtypes (n=70) and control patients (n=10) without cancer diagnosis. We applied indirect immunohistochemistry and evaluated immunostaining. CD133 expression was at the periphery and CXCR1 expression was at the central area of the tumor. The cytoplasmic CXCR1, CD133 expressions and nuclear CD133 expression, which is prominent in the TN subtype, were observed in patients. There was a statistically significant difference between the groups for CD133 (p=0.004), CXCR1 (p=0.002) H-Score values and M2 macrophages/whole TAM ratios (p=0.022). Between the CD133 and CXCR1 H-scores, there was a weak positive correlation (r=0.249, p=0.035). This study showed the compartment specific expression of the CD133 and CXCR1 antigens in neoplastic cells. The use of CD133 as a stem cell marker may be limited to TN subtype, due to its heterogeneous expression.en_US
dc.description.sponsorshipTeaching Staff Training Program of Council of Higher Education [GO 15/174-05]en_US
dc.description.sponsorshipThis study with project number GO 15/174-05 was granted by Teaching Staff Training Program of Council of Higher Education.en_US
dc.identifier.doi10.14670/HH-18-139
dc.identifier.endpage96en_US
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.issue1en_US
dc.identifier.pmid31250425en_US
dc.identifier.scopus2-s2.0-85077402885en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage83en_US
dc.identifier.urihttps://doi.org/10.14670/HH-18-139
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19363
dc.identifier.volume35en_US
dc.identifier.wosWOS:000502592900007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherF Hernandezen_US
dc.relation.ispartofHistology And Histopathologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectNeoplastic Stem Cellsen_US
dc.subjectInterleukin-8Aen_US
dc.subjectMacrophages/Pathologyen_US
dc.subjectTumor Microenvironmenten_US
dc.subjectStem-Cellsen_US
dc.subjectExpressionen_US
dc.subjectTargetsen_US
dc.subjectRisken_US
dc.titleThe evaluation of the distribution of CD133, CXCR1 and the tumor associated macrophages in different molecular subtypes of breast canceren_US
dc.typeConference Objecten_US

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