Ebselen protects against oxidative and morphological effects of high concentration chronic toluene exposure on rat sciatic nerves

Basit Öğe Kaydı
dc.authorscopusid7003600530
dc.authorscopusid6602231180
dc.authorscopusid7006356462
dc.authorscopusid15847888700
dc.contributor.authorCoşkun Ö.
dc.contributor.authorYüncü M.
dc.contributor.authorKanter M.
dc.contributor.authorBüyükbaş S.
dc.date.accessioned2024-06-12T10:25:57Z
dc.date.available2024-06-12T10:25:57Z
dc.date.issued2006
dc.description.abstractAim: Neuroprotective effects of ebselen against free radical damage have been studied extensively. Toluene generates reactive oxygen species (ROS) and the toxic effects relating to these reactants. The aim of this study was designed to investigate the effects of chronic toluene inhalation in high concentration on lipid peroxidation, antioxidant enzyme activities and ultrastructural changes in the sciatic nerves of rats. Methods: We also examined the protective effects of ebselen against toluen exposure. Male Wistar albino rats (150-250 g) were divided in three experimental groups: the control, toluene and toluene+ebselen treated group (n=10 for each). Toluene treatment was performed by inhalation of 3000 ppm toluene, in a 8 hr/day and 6 day/week order for 16 weeks. Control group received 1ml serum physiologic and ebselen was given i.p. (10 mg/kg) to toluene+ebselen treated group just after toluene exposure per day. Blood and tissue samples were obtained for biochemical and histopathological investigation. The blood and sciatic nerves were assayed for toluene by gas chromatography. Results: Toluene significantly increased blood and tissue malondialdehyde (MDA), and decreased tissue superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), but not tissue catalase (CAT) levels when compared with controls. Ebselen administration prevented to increase of blood and tissue MDA and decrease to SOD and GSH-Px levels induced by toluene inhalation. Electron micrographs of sciatic nerve in the toluene group shows myelin destructions with onion-bulb and bubble form protrusion on the myelin sheath and axolemma border of myelinated axons. Furthermore, ebselen salvaged the nerve fibers from toluene exposure. Conclusion: Ebselen treatment may provide neuroprotection against toluene neurotoxicity by directly scavenging ROS and by indirectly augmenting their antioxidant capacity.en_US
dc.identifier.doi10.29333/ejgm/82380
dc.identifier.endpage72en_US
dc.identifier.issn1304-3889
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-34249058679en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage64en_US
dc.identifier.urihttps://doi.org/10.29333/ejgm/82380
dc.identifier.urihttps://hdl.handle.net/20.500.14551/16574
dc.identifier.volume3en_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTIP ARASTIRMALARI DERNEGIen_US
dc.relation.ispartofEuropean Journal of General Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntioxidant Enzymes; Ebselen; Lipid Peroxidation; Sciatic Nerve; Toluene; Ultrastructuralen_US
dc.subjectCatalase; Ebselen; Glutathione Peroxidase; Malonaldehyde; Reactive Oxygen Metabolite; Superoxide Dismutase; Toluene; Animal Experiment; Animal Tissue; Antioxidant Activity; Article; Blood Level; Controlled Study; Enzyme Activity; Gas Chromatography; Histopathologic Skin Reaction; Lipid Peroxidation; Long Term Exposure; Male; Neuroprotection; Neurotoxicity; Nonhuman; Rat; Sciatic Nerve; Tissue Levelen_US
dc.titleEbselen protects against oxidative and morphological effects of high concentration chronic toluene exposure on rat sciatic nervesen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu