The effect of nadroparine on coagulation mechanisms

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dc.authoridHalici, Umit/0000-0002-1289-8829
dc.authoridHalici, Umit/0000-0002-1289-8829
dc.authoridSunar, Hasan/0000-0002-1276-8549
dc.authorwosidHalici, Umit/AAL-7079-2020
dc.authorwosidHalici, Umit/C-4015-2019
dc.authorwosidSunar, Hasan/A-8685-2018
dc.contributor.authorSunar, H
dc.contributor.authorHüseyinova, G
dc.contributor.authorCanbaz, S
dc.contributor.authorHalici, Ü
dc.contributor.authorDuran, E
dc.date.accessioned2024-06-12T11:08:56Z
dc.date.available2024-06-12T11:08:56Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractLow molecular weight heparins are widely used in the prophylaxis and treatment of thrombotic disorders. The effect of low molecular weight heparins on coagulation was examined ultrastructurally in an animal model. A test and a control group was formed, each consisting of five rabbits. Nadroparine (225 Institute of Chaoy Unit/kg twice daily) was applied to the test group for 10 days. The control group received 1 ml saline solution subcutaneously. Blood and vascular tissue samples collected at the end of the 10th day were evaluated under a JEM 100 B electron microscope. Platelet degranulation and agglutination was observed in the control group. Fibrin materials were detected in the cytoplasms and surroundings of degranulated platelets. Erythrocyte accumulation was remarkable on the vascular endothelium with intact coagulation periods. In the test group, outer membranes of platelets, hyalomere, and granular structures in the granulomeres were detected to be nearly intact. There were rare erythrocytes in the large vascular lumens. The aggregation phase had occurred but no agglutination was detected. Nadroparine seems to preserve consistency of lipoprotein membranes of platelets and granular structures containing enzymes, which contribute to the coagulation mechanisms. (C) 2003 Lippincott Williams Wilkins.en_US
dc.identifier.doi10.1097/00001721-200312000-00002
dc.identifier.endpage706en_US
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.issue8en_US
dc.identifier.pmid14614347en_US
dc.identifier.scopus2-s2.0-21244465550en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage703en_US
dc.identifier.urihttps://doi.org/10.1097/00001721-200312000-00002
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22619
dc.identifier.volume14en_US
dc.identifier.wosWOS:000222308000002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofBlood Coagulation & Fibrinolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNadroparineen_US
dc.subjectLow Molecular Weight Heparinsen_US
dc.subjectPlateletsen_US
dc.subjectCoagulationen_US
dc.subjectHemostasisen_US
dc.subjectElectron Microscopyen_US
dc.subjectUltrastructural Changesen_US
dc.subjectMolecular-Weight Heparinsen_US
dc.subjectDeep Venous Thrombosisen_US
dc.subjectUnfractionated Heparinen_US
dc.subjectInitial Treatmenten_US
dc.titleThe effect of nadroparine on coagulation mechanismsen_US
dc.typeArticleen_US

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