Evaluation of Anticholinergic, Antidiabetic and Antioxidant Activity of Astragalus dumanii, an Endemic Plant

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dc.authoridGulcin, ilhami/0000-0001-5993-1668
dc.authoridKocyigit, Umit Muhammet/0000-0001-8710-2912
dc.authoridgokalp, faik/0000-0003-4363-3839
dc.authorid, Nuraniye/0000-0002-4674-7009
dc.authoridAtas, Mehmet/0000-0002-9425-0080
dc.authoridTekin, Mehmet/0000-0002-1157-1314
dc.authoridTaslimi, Parham/0000-0002-3171-0633
dc.authorwosidTaslimi, Parham/AAL-2788-2020
dc.authorwosidGulcin, ilhami/F-1428-2014
dc.contributor.authorKocyigit, Umit Muhammet
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorAtas, Mehmet
dc.contributor.authorTekin, Mehmet
dc.contributor.authorTaslimi, Parham
dc.contributor.authorGokalp, Faik
dc.contributor.authorGulcin, Ilhami
dc.date.accessioned2024-06-12T10:52:44Z
dc.date.available2024-06-12T10:52:44Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe research was conducted to separately evaluate and detect the possible in vitro antioxidant, antimicrobial activity of ethanol extracts prepared from aerial parts and roots of Astragalus dumanii and anti-cholinesterase and alpha-glucosidase inhibitory activity from only aerial parts of its The antioxidant capacity was tested by scavenging of DPPH and ABTS free radicals. Compared with the standard antioxidant compound gallic acid; Root and aerial part extract showed lower DPPH radical scavenging activity, however aerial part extract demonstrated higher ABTS radical scavenging activity. The phenolic contents were detected as 5.31 +/- 0.03 and 13.23 +/- 0.05 mg gallic acid equivalent g-1 extract, flavonoid contents were found as 8.26 +/- 0.004 and 7.93 +/- 0.005 mg Qercetin equivalent g-1 extract. In addition, the effects of the extracts obtained from aerial parts of the plant on acetylcholinesterase, butyrylcholinesterase and a-glycosidase enzymes were investigated in vitro and IC50 values were obtained as 1.47, 0.83 and 0.48 mu g mL-1, respectively. When these values were compared with standard substances, it was seen that Astragalus dumanii could be a good enzyme inhibitory agent. Antimicrobial activity of the plant extracts were determined using the microdilution method and the extracts was not observed to have any antimicrobial activities..en_US
dc.identifier.doi10.18016/ksutarimdoga.vi.895616
dc.identifier.endpage10en_US
dc.identifier.issn2619-9149
dc.identifier.startpage1en_US
dc.identifier.trdizinid1171146en_US
dc.identifier.urihttps://doi.org/10.18016/ksutarimdoga.vi.895616
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1171146
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18800
dc.identifier.volume25en_US
dc.identifier.wosWOS:000899419700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherKahramanmaras Sutcu Imam Univ Rektorluguen_US
dc.relation.ispartofKsu Tarim Ve Doga Dergisi-Ksu Journal Of Agriculture And Natureen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAstragalus Dumaniien_US
dc.subjectAntioxidanten_US
dc.subjectAntidiabeticen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectCarbonic-Anhydraseen_US
dc.subjectAcetylcholinesteraseen_US
dc.subjectButyrylcholinesteraseen_US
dc.subjectInhibitorsen_US
dc.subjectExtractsen_US
dc.titleEvaluation of Anticholinergic, Antidiabetic and Antioxidant Activity of Astragalus dumanii, an Endemic Planten_US
dc.typeArticleen_US

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