Pt(II) complex of Schiff base derived from L-phenylalanine and furfuraldehyde in the presence of 8-hydroxyquinoline: Structural analysis, composition of complex and biological activity

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dc.contributor.authorAltun, Ozlen
dc.contributor.authorKocer, Melike Ozge
dc.date.accessioned2024-06-12T11:15:55Z
dc.date.available2024-06-12T11:15:55Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn the present study, we synthesized a Schiff base (L-1) derived from L-phenylalanine with furfuraldehyde and its Pt(II) complex ([Pt(L-1) (L-2)]: [Pt(N-(furfuralidene)phenylalanine) (8-hydroxyquinoline)]) in the presence of 8-hydroxyquinoline (L-2). The chemical structures of the synthesized Schiff base and Pt(II) complex were characterized using ESI-MS, UV-Visible, FT-IR, H-1 NMR, C-13 NMR, and powder-XRD spectroscopy. The surface morphologies and elemental composition were determined by SEM and EDX. Thermal analysis was performed with TG-DTA. Mole ratio of Meyer and Job methods were used for the composition of complexes. According to these methods, the ratio [Pt2+] : [L-1 + L-2] was found to be 1 : 1. In addition, the antimicrobial activities of L-1 and the complex showed that the compounds have significant antibacterial and antifungal properties. They also show important cytotoxic effects against the growth of mouse embryo fibroblasts (MEF) and human prostate adenocarcinoma (Du145) cancer cells. L-1, L-2, and the Pt(II) complex also displayed effective antioxidant activity.en_US
dc.description.sponsorshipTrakya University, Research Fund (TUBAP) [2016/250]en_US
dc.description.sponsorshipThis study was financially supported by Trakya University, Research Fund (TUBAP, project #2016/250). We (Assoc Prof Ozlen ALTUN and Research Student Melike Ozge KOCER) confirm that Trakya University only provided financial support within the scope of the project for chemicals in the manuscript and we declare that the support received did not lead to any conflict of interests regarding the publication of this manuscript. There is no need for Trakya University's confirmation to publish this manuscript.en_US
dc.identifier.doi10.5802/crchim.9
dc.identifier.endpage142en_US
dc.identifier.issn1631-0748
dc.identifier.issn1878-1543
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85103409359en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage127en_US
dc.identifier.urihttps://doi.org/10.5802/crchim.9
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24124
dc.identifier.volume23en_US
dc.identifier.wosWOS:000573968300003en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCentre Mersenne Pour Ldition Scientifique Ouverteen_US
dc.relation.ispartofComptes Rendus Chimieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSynthesisen_US
dc.subjectSpectral Characterizationen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectCytotoxic Activityen_US
dc.subjectAntioxidant Activityen_US
dc.subjectMixed-Ligand Complexesen_US
dc.subjectTransition-Metal-Complexesen_US
dc.subjectDicarboxylic Amino-Acidsen_US
dc.subjectDna-Binding Propertiesen_US
dc.subjectIn-Vitro Cytotoxicityen_US
dc.subjectCrystal-Structureen_US
dc.subjectPlatinum(Ii) Complexesen_US
dc.subjectAntimicrobial Activityen_US
dc.subjectAntioxidant Activityen_US
dc.subjectManganese(Iii) Complexesen_US
dc.titlePt(II) complex of Schiff base derived from L-phenylalanine and furfuraldehyde in the presence of 8-hydroxyquinoline: Structural analysis, composition of complex and biological activityen_US
dc.typeArticleen_US

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