The bronchoalveolar epithelial permeability in house painters as determined by Tc-99m DTPA aerosol scintigraphy

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dc.authoridTABAKOGLU, ERHAN/0000-0003-1315-4538
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorKaya, M
dc.contributor.authorSalan, A
dc.contributor.authorTabakoglu, E
dc.contributor.authorAydogdu, N
dc.contributor.authorBerkarda, S
dc.date.accessioned2024-06-12T11:03:22Z
dc.date.available2024-06-12T11:03:22Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPurpose: Isocyanates are highly reactive chemicals used in a number of industries including paints. Therefore, house painters are known to be at risk for occupational exposure to isocyanates. Our objectives in this study were: (1) to investigate the possible effects of isocyanate exposition on the bronchoalveolar epithelial permeability in house painters by using Tc-99m DTPA radioaerosol lung scintigraphy; (2) to assess whether or not some differences exist between asthmatic and non-asthmatic house painters, and (3) to determine the relationship between Tc-99m DTPA radioaerosol lung scintigraphy and the spirometric measurements, and the work duration of house painters. Materials and Methods: Ten non-smoking house painters (28.8 +/- 8.8 yrs) and ten healthy volunteers underwent Tc-99m DTPA radioaerosol lung scintigraphy. Following inhalation of radiotracer through a nebulizer for 5 minutes, dynamic scintigrams (1 frame/min, up to 10 min) were taken from both lungs. ROI's were drawn over the both lung area, and time-activity curves were obtained, from which the half-time (T-1/2) of Tc-99m DTPA clearance was calculated. Spirometric lung function test was measured in all house painters. Results: Mean T1/2 values (min +/- SD) were 93.74 +/- 32.79 for house painters, and 90.96 +/- 40.02 for control subjects. There was no significant difference in T1/2 values of Tc-99m DTPA clearance between house painters and controls, and between asthmatic and non-asthmatic house painters as well. No correlation was observed between Tin values of Tc-99m DTPA clearance and spirometric measurements. In house painters, there was a positive correlation between T1/2 values of Tc-99m DTPA clearance and work duration (r = 0.73, p = 0.016). Conclusions: Our findings indicate that in house painters, occupational exposure to isocyanates has no effect on bronchoalveolar epithelial permeability, and the rate of Tc-99m DTPA clearance shows no difference between asthmatic and non-asthmatic house painters. The positive correlation between the rate of Tc-99m DTPA clearance and work duration needs to be confirmed in larger cohorts.en_US
dc.identifier.doi10.1007/BF02988526
dc.identifier.endpage308en_US
dc.identifier.issn0914-7187
dc.identifier.issn1864-6433
dc.identifier.issue4en_US
dc.identifier.pmid12932114en_US
dc.identifier.scopus2-s2.0-0041512896en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage305en_US
dc.identifier.urihttps://doi.org/10.1007/BF02988526
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21633
dc.identifier.volume17en_US
dc.identifier.wosWOS:000184517000005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals Of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHouse Paintersen_US
dc.subjectTc-99m DTPA Aerosol Scintigraphyen_US
dc.subjectBronchoalveolar Permeabilityen_US
dc.subjectToluene Diisocyanateen_US
dc.subjectOccupational Asthmaen_US
dc.subjectClearanceen_US
dc.subjectDiseaseen_US
dc.subjectInflammationen_US
dc.subjectAbsorptionen_US
dc.subjectSmokersen_US
dc.titleThe bronchoalveolar epithelial permeability in house painters as determined by Tc-99m DTPA aerosol scintigraphyen_US
dc.typeArticleen_US

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