PIFA [feniliyodo (III) bis trifloroasetat] ile hidroksi fenil ketoksimlerin halka kapanma reaksiyonlarının incelenmesi
Küçük Resim Yok
Tarih
2003
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Trakya Üniversitesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Doktora Tezi Trakya Üniversitesi Fen Bilimleri Enstitüsü Kimya Anabilim Dalı ÖZET Bu çalışmada, l-oxa-2-aza [5,5] undeca türevi maddelerin sentezi denenmiştir. Hedeflenen ürünün sentezi için önce hidroksifenil ketonlar sentezlenmeye çalışılmış, bunun için indirgenme, ^rignard reaksiyonu, yükseltgenme gibi bir seri reaksiyon gerçekleştirilmiş ve istenilen ketonlar elde edilmiştir. Dana sonra sentezlenen bu ketonlar oksimine çevrilerek elde edilen oksimlerin PIFA [fenil iyodo (IH) bis trifloroasetat] ve IBX (o-iyodoksibenzoik asit) ile halka kapanma reaksiyonları denenmiştir. Bu reaksiyonlar sonucunda düşük verimle de olsa PIFA ile umulan ürünler elde edilirken, IBX ile istenilen spiroizoksazolin türevi bileşikler elde edilememiştir. Anahtar sözcükler; Cyclisation (siklizasyon), oxime (oksim), PIFA [fenil iyodo (III) bis trifloroasetat], IBX (o-iyodoksibenzoik asit), spiro (halka yapılar) 2003 Yılı 106 Sayfa
PhD Thesis Trakya University Graduate School of Natural and Applied Science Department of Chemistry ABSTRACT In the present study, it was attempted to synthesize the derivative of l-oxa-2-aza [5,5] undeca compounds. For the synthesis of the intended product, firstly, hydroxyphenyl ketones were obtained by applying a series of reactions such as reduction, Grignard and oxidation reactions, and the intended ketones were produced. Secondly, those ketones were transformed into the oximes and cyclisation reactions using PIFA [phenyl iodo (HI) bis triflouroacetate] and IBX (o-iodoxybenzoic acid) reagents were tested. As the result of these reactions, expected products were obtained with PIFA though with low yield. However, spiroisoxazolin derivative compounds could not obtained with IBX. Keywords: Cyclisation, oxime, PIFA [phenyl iodo (III) bis triflouroacetate], IBX (o-iodoxybenzoic acid), spiro. Year : 2003 Pages : 106
PhD Thesis Trakya University Graduate School of Natural and Applied Science Department of Chemistry ABSTRACT In the present study, it was attempted to synthesize the derivative of l-oxa-2-aza [5,5] undeca compounds. For the synthesis of the intended product, firstly, hydroxyphenyl ketones were obtained by applying a series of reactions such as reduction, Grignard and oxidation reactions, and the intended ketones were produced. Secondly, those ketones were transformed into the oximes and cyclisation reactions using PIFA [phenyl iodo (HI) bis triflouroacetate] and IBX (o-iodoxybenzoic acid) reagents were tested. As the result of these reactions, expected products were obtained with PIFA though with low yield. However, spiroisoxazolin derivative compounds could not obtained with IBX. Keywords: Cyclisation, oxime, PIFA [phenyl iodo (III) bis triflouroacetate], IBX (o-iodoxybenzoic acid), spiro. Year : 2003 Pages : 106
Açıklama
Bu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır. Yayınlanma izni olmayan tezlerin basılı kopyalarına Üniversite kütüphaneniz aracılığıyla (TÜBESS üzerinden) erişebilirsiniz.
Doktora
Doktora
Anahtar Kelimeler
Kimya, Chemistry
