Possible Ototoxic Effects of Topical Rifamycin Application: An Electrophysiological and Ultrastructural Study

Basit Öğe Kaydı
dc.authorwosidBULUT, Erdoğan/C-4135-2015
dc.contributor.authorAbayli, Cihan
dc.contributor.authorKul, Yusuf
dc.contributor.authorKoten, Muhsin
dc.contributor.authorKarasalihoglu, Ahmet Rifat
dc.contributor.authorTas, Abdullah
dc.contributor.authorYagiz, Recep
dc.contributor.authorBulut, Erdogan
dc.date.accessioned2024-06-12T11:13:42Z
dc.date.available2024-06-12T11:13:42Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: This study aimed to investigate possible ototoxicity associated with topical rifamycin application via electrophysiological tests and ultrastructural examinations. Methods: Electrophysiological assessment was performed with tympanometry, auditory brainstem response (ABR), and distortion product otoacoustic emission (DPOAE) measurements. This study was conducted on 40 ears of 20 guinea pigs that were detected to have normal hearing thresholds. The animals were randomly assigned to three groups: Group 1 (n=12) received 0.1 mL rifamycin, Group 2 (n=8) received 0.1 ml gentamycin, and Group 3 (n=20) received 0.1 mL physiological saline. The antibiotics and saline solutions were administered via intratympanic injections. After five injections every other day, electrophysiological tests were performed again on the 15th day. After electrophysiological measurements, the temporal bones of all guinea pigs were prepared for ultrastructural examinations and the cochlear surface morphology was examined by scanning electron microscopy (SEM). Results: The animals in group 3 did not show a statistically significant change in their DPOAE signal/noise ratio (SNR) or ABR thresholds (p>0.05). In groups 1 and 2, the reduction in the DPOAE SNR and the increase in the ABR threshold were statistically significant (p<0.05). Regarding SEM examination results, the animals in groups 1 and 2 showed statistically significant outer hair cell damage and cochlear degeneration due to the ototoxic effect of the drugs (p<0.05), whereas the animals in group 3 showed no significant damage (p>0.05). Conclusion: The results indicate that rifamycin application to the middle ears of guinea pigs has mild ototoxic effects on their inner ears.en_US
dc.identifier.doi10.5152/tao.2017.2391
dc.identifier.endpage104en_US
dc.identifier.issn2667-7466
dc.identifier.issn2667-7474
dc.identifier.issue3en_US
dc.identifier.pmid29392065en_US
dc.identifier.startpage99en_US
dc.identifier.trdizinid232026en_US
dc.identifier.urihttps://doi.org/10.5152/tao.2017.2391
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/232026
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23659
dc.identifier.volume55en_US
dc.identifier.wosWOS:000412200600002en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofTurkish Archives Of Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRifamycinen_US
dc.subjectOtotoxicityen_US
dc.subjectOtoacoustic Emissionen_US
dc.subjectAuditory Brainstem Responseen_US
dc.subjectScanning Electron Microscopyen_US
dc.subjectGuinea Pigen_US
dc.subjectDistortionen_US
dc.subjectCisplatinen_US
dc.titlePossible Ototoxic Effects of Topical Rifamycin Application: An Electrophysiological and Ultrastructural Studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu