Differentiation of vascular dementia and Alzheimer disease - A functional transcranial Doppler ultrasonographic study

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dc.authoridUzuner, Nevzat/0000-0002-4961-4332
dc.authoridUZUNER, NEVZAT/0000-0002-4961-4332
dc.authorwosidUzuner, Nevzat/ABB-5971-2020
dc.authorwosidUZUNER, NEVZAT/B-3367-2018
dc.contributor.authorAsil, T
dc.contributor.authorUzuner, N
dc.date.accessioned2024-06-12T10:51:21Z
dc.date.available2024-06-12T10:51:21Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective. in brain perfusion studies, perfusion defects have been reported mainly in the temporal and parietal regions in patients with Alzheimer disease (AD), but it is known that the occipital cortex is partially preserved from metabolic defects in patients with AD, at least in the early stage of the disease. We therefore evaluated the reactivity of the posterior cerebral arteries during visual stimulation with transcranial Doppler ultrasonography (TDU). Methods. Fifteen patients with AD (mean age, 70 years), 12 patients with vascular dementia (VD) (mean age, 61.5 years), and 9 healthy control subjects (mean age, 58 years) were enrolled in the study. The reactivity of both posterior cerebral arteries during visual stimulation was measured with TDU. Reactivity was calculated by the differences in mean relative blood flow velocity (rBFv) between stimulation (vs) and rest (vr) divided by the resting value [rBFv = 100 x (vs - vr)/vr]. Results. Significant increases of vascular reactivity were obtained during visual stimulation for each group (P <.001). There was no significant right or left side difference for vascular reactivity within the groups except in VD,- therefore, values of the right and left sides were pooled for patients with AD and control subjects. Reactivity to visual stimulation was similar for the patients with AD (mean +/- SD, 38% +/- 2.2%) and control subjects (35% +/- 1.8%), but reactivity was found significantly decreased in both sides of patients with VD (25.7% +/- 2.1% for the left side and 24% +/- 2.6% for the right side) compared with the healthy control subjects and the patients with AD (P <.001). Conclusions. These results indicate that the occipital cortex is partially preserved in patients with AD and that functional TDU may be a valuable tool for differentiating VD and AD.en_US
dc.identifier.doi10.7863/jum.2005.24.8.1065
dc.identifier.endpage1070en_US
dc.identifier.issn0278-4297
dc.identifier.issn1550-9613
dc.identifier.issue8en_US
dc.identifier.pmid16040820en_US
dc.identifier.scopus2-s2.0-23044486695en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1065en_US
dc.identifier.urihttps://doi.org/10.7863/jum.2005.24.8.1065
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18334
dc.identifier.volume24en_US
dc.identifier.wosWOS:000230831200005en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Ultrasound In Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlzheimer Diseaseen_US
dc.subjectDementiaen_US
dc.subjectTranscranial Doppler Ultrasonographyen_US
dc.subjectVascular Dementiaen_US
dc.subjectCerebral Hemodynamic Patternsen_US
dc.subjectBlood-Flowen_US
dc.subjectMultiinfarcten_US
dc.subjectSonographyen_US
dc.subjectTomographyen_US
dc.subjectVelocityen_US
dc.subjectSpecten_US
dc.titleDifferentiation of vascular dementia and Alzheimer disease - A functional transcranial Doppler ultrasonographic studyen_US
dc.typeArticleen_US

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