Protective effects of thymoquinone against cholestatic oxidative stress and hepatic damage after biliary obstruction in rats

Simple item page
dc.authorwosidOguz, Serhat/HKE-2793-2023
dc.contributor.authorOguz, Serhat
dc.contributor.authorKanter, Mehmet
dc.contributor.authorErboga, Mustafa
dc.contributor.authorErenoglu, Cengiz
dc.date.accessioned2024-06-12T11:16:21Z
dc.date.available2024-06-12T11:16:21Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to examine the preventive and therapeutic effects of thymoquinone (TQ) against cholestatic oxidative stress and liver damage in common bile duct ligated rats. A total of 24 male Sprague-Dawley rats were divided into three groups: control, bile duct ligation (BDL) and BDL + received TQ; each group contain 8 animals. The rats in TQ treated groups were given TQ (50 mg/kg body weight) once a day orally for 2 weeks starting 3 days prior to BDL operation. To date, no more biochemical and histopathological changes on common bile duct ligated rats by TQ treatment have been reported. The application of BDL clearly increased the tissue hydroxyproline (HP) content, malondialdehyde (MDA) levels and decreased the antioxidant enzyme [superoxide dismutase (SOD), glutathione peroxidase (GPx)] activities. TQ treatment significantly decreased the elevated tissue HP content, and MDA levels and raised the reduced of SOD, and GPx enzymes in the tissues. The changes demonstrating the bile duct proliferation and fibrosis in expanded portal tracts include the extension of proliferated bile ducts into lobules, mononuclear cells, and neutrophil infiltration into the widened portal areas were observed in BDL group. Treatment of BDL with TQ attenuated alterations in liver histology. The immunopositivity of alpha smooth muscle actin and proliferating cell nuclear antigen in BDL were observed to be reduced with the TQ treatment. The present study demonstrates that oral administration of TQ in bile duct ligated rats maintained antioxidant defenses and reduces liver oxidative damage and ductular proliferation. This effect of TQ may be useful in the preservation of liver function in cholestasis.en_US
dc.identifier.doi10.1007/s10735-011-9390-y
dc.identifier.endpage159en_US
dc.identifier.issn1567-2379
dc.identifier.issn1567-2387
dc.identifier.issue2en_US
dc.identifier.pmid22270828en_US
dc.identifier.scopus2-s2.0-84861062975en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage151en_US
dc.identifier.urihttps://doi.org/10.1007/s10735-011-9390-y
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24288
dc.identifier.volume43en_US
dc.identifier.wosWOS:000303357100004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Molecular Histologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThymoquinoneen_US
dc.subjectOxidative Stresen_US
dc.subjectImmunohistochemistryen_US
dc.subjectLiveren_US
dc.subjectBile Duct Ligationen_US
dc.subjectRatsen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectLiver-Damageen_US
dc.subjectExperimental-Modelen_US
dc.subjectNigella-Sativaen_US
dc.subjectVitamin-Een_US
dc.subjectBileen_US
dc.subjectInjuryen_US
dc.subjectCellsen_US
dc.subjectCirrhosisen_US
dc.subjectMitochondriaen_US
dc.titleProtective effects of thymoquinone against cholestatic oxidative stress and hepatic damage after biliary obstruction in ratsen_US
dc.typeArticleen_US

Files

Collections

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu