CD11B EXPRESSION IN ACUTE MYELOID LEUKEMIA IS ASSOCIATED WITH HEMOSTATIC COMPLICATIONS AND RESPONSE TO TREATMENT

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dc.contributor.authorBaysal, Mehmet Kemal
dc.contributor.authorÜmit, Elif G.
dc.contributor.authorÖztürk, Gökhan
dc.contributor.authorGülsaran, Sedanur Karaman
dc.contributor.authorBaş, Volkan
dc.contributor.authorKırkızlar, Hakkı Onur
dc.contributor.authorDemir, Ahmet Muzaffer
dc.date.accessioned2024-06-12T10:05:18Z
dc.date.available2024-06-12T10:05:18Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: In our study, we aimed to investigate the effects of CD11b expression on myeloblasts on clinical course and prognosis in patients with AML. Materials and Methods: Data of 123 patients diagnosed with AML between 2014-2017 in Trakya University Faculty of Medicine, Department of Hematology, a tertiary referral hospital in the Trakya Region, were evaluated in a retrospective manner. The diagnosis of AML was based on WHO 2016 criteria of Myeloid Neoplasms. Results: Of the 123 patients in our study, 60 were female, and 63 were male. The mean age was 57.93 years. CD11b positivity was observed in 40 patients. Platelet counts were significantly lower in patients with CD11b positivity (p = 0.004). Likewise, D-dimer levels at presentation were higher in the CD11b positive patient group (p = 0.000). Regarding outcomes, patients with CD11b positivity were found to have lower rates of remission with first-line remission induction therapy (p = 0.003). There was no significant relationship between CD11b positivity and overall survival with Kaplan Meier survival analysis (8.5 months in CD 11b positive group, 12.1 months in negative group, p: 0.436). Conclusion: Our study demonstrated that patients with CD11b expression had lower remission rates with remission induction chemotherapy.en_US
dc.identifier.doi10.37696/nkmj.603530
dc.identifier.endpage21en_US
dc.identifier.issn2587-0262
dc.identifier.issue1en_US
dc.identifier.startpage16en_US
dc.identifier.trdizinid362468en_US]
dc.identifier.urihttps://doi.org/10.37696/nkmj.603530
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/362468
dc.identifier.urihttps://hdl.handle.net/20.500.14551/13357
dc.identifier.volume8en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofNamık Kemal Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleCD11B EXPRESSION IN ACUTE MYELOID LEUKEMIA IS ASSOCIATED WITH HEMOSTATIC COMPLICATIONS AND RESPONSE TO TREATMENTen_US
dc.typeArticleen_US

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