Postmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy?

Basit Öğe Kaydı
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridÖzen, Alaattin/0000-0001-9219-6001
dc.authoridCosar, Rusen/0000-0002-7953-8887
dc.authoridDepboylu Denizli, Bengu/0000-0002-9777-2917
dc.authoridCosar, Rusen/0000-0002-7953-8887;
dc.authorwosidÖzen, Alaattin/ABG-9988-2020
dc.authorwosidÖzen, Alaattin/IZQ-0388-2023
dc.authorwosidKocak, Zafer/AEG-7828-2022
dc.authorwosidCosar, Rusen/GQP-7875-2022
dc.authorwosidDepboylu Denizli, Bengu/B-9156-2019
dc.authorwosidCosar, Rusen/AAC-4045-2020
dc.authorwosidIbis, Kamuran/AAD-1939-2019
dc.contributor.authorCosar, Rusen
dc.contributor.authorUzal, Cem
dc.contributor.authorTokatli, Fusun
dc.contributor.authorDenizli, Bengu
dc.contributor.authorSaynak, Mert
dc.contributor.authorTuran, Nesrin
dc.contributor.authorUzunoglu, Sernaz
dc.date.accessioned2024-06-12T11:19:02Z
dc.date.available2024-06-12T11:19:02Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: We aimed to evaluate retrospectively the correlation of loco-regional relapse (LRR) rate, distant metastasis (DM) rate, disease free survival (DFS) and overall survival (OS) in a group of breast cancer (BC) patients who are at intermediate risk for LRR (T1-2 tumor and 1-3 positive axillary nodes) treated with or without postmastectomy radiotherapy (PMRT) following modified radical mastectomy (MRM). Methods: Ninety patients, with T1-T2 tumor, and 1-3 positive nodes who had undergone MRM received adjuvant systemic therapy with (n = 66) or without (n = 24) PMRT. Patient-related characteristics (age, menopausal status, pathological stage/tumor size, tumor location, histology, estrogen/progesterone receptor status, histological grade, nuclear grade, extracapsular extension, lymphatic, vascular and perineural invasion and ratio of involved nodes/dissected nodes) and treatment-related factors (PMRT, chemotherapy and hormonal therapy) were evaluated in terms of LRR and DM rate. The 5-year Kaplan-Meier DFS and OS rates were analysed. Results: Differences between RT and no-RT groups were statistically significant for all comparisons in favor of RT group except OS: LRR rate (3% vs 17%, p = 0.038), DM rate (12% vs 42%, p = 0.004), 5 year DFS (82.4% vs 52.4%, p = 0.034), 5 year OS (90,2% vs 61,9%, p = 0.087). In multivariate analysis DM and lymphatic invasion were independent poor prognostic factors for OS. Conclusion: PMRT for T1-2, N1-3 positive BC patients has to be reconsidered according to the prognostic factors and the decision has to be made individually with the consideration of long-term morbidity and with the patient approval.en_US
dc.identifier.doi10.1186/1748-717X-6-28
dc.identifier.issn1748-717X
dc.identifier.pmid21450076en_US
dc.identifier.scopus2-s2.0-79953086351en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1186/1748-717X-6-28
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25060
dc.identifier.volume6en_US
dc.identifier.wosWOS:000289298500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofRadiation Oncologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHigh-Risken_US
dc.subjectLocoregional Recurrenceen_US
dc.subjectPrognostic-Factoren_US
dc.subjectRadiotherapyen_US
dc.subjectSurvivalen_US
dc.subjectRatioen_US
dc.subjectMastectomyen_US
dc.subjectStatementen_US
dc.subjectNumberen_US
dc.titlePostmastectomy irradiation in breast in breast cancer patients with T1-2 and 1-3 positive axillary lymph nodes: Is there a role for radiation therapy?en_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu