Effect of alterations in apoptotic pathway on development of metabolic syndrome in patients with psoriasis vulgaris

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dc.authorwosidKorkmaz, Selma/JRX-3713-2023
dc.contributor.authorKorkmaz, S.
dc.contributor.authorKorkmaz, H.
dc.date.accessioned2024-06-12T11:18:55Z
dc.date.available2024-06-12T11:18:55Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground An increase in the incidence of metabolic syndrome (MetS) has been identified in patients with psoriasis. Objectives To evaluate the role of changes in expression of apoptosis activators [B-cell lymphoma (Bcl)-2-like protein 4 (BAX), cytochrome c (cytC) and caspase-3 (CASP3)] and apoptosis inhibitors [Bcl-2, survivin, cyclin D1 (CCND1), superoxide dismutase (SOD), catalase 3 (CAT), glutathione synthetase (GS), heat shock protein (Hsp)27, Hsp60, Hsp70 and Hsp90] on development of MetS in patients with psoriasis vulgaris. Methods Fifty patients with psoriasis were enrolled; 25 had MetS. Twenty-five healthy people and 25 people with only MetS were included as a control group. Serum fasting blood glucose, urea, creatinine, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, thyroid-stimulating hormone, fraction of thyroxine, fasting insulin and highly sensitive C-reactive protein levels were measured. Expression of BAX, cytC, CASP3, Bcl-2, survivin, CCND1, SOD, CAT, GS, and Hsp27, Hsp60, Hsp70 and Hsp90 were measured in peripheral blood. Clinical activation of patients with psoriasis was calculated using Psoriasis Area and Severity Index scores. Results In patients with MetS there was an increase in expression of genes for cytC, survivin and Hsp27, Hsp60 and Hsp90, and a decrease in expression of CCND1. Furthermore, expression levels of CCND1 were identified to be an independent risk factor for MetS development in patients with psoriasis. Conclusions The increase in expression of survivin and Hsp27, Hsp60 and Hsp90, and the decrease in CCND1 expression may be important mechanisms in the development of MetS in patients with psoriasis.en_US
dc.description.sponsorshipTrakya University Scientific Research Support Funden_US
dc.description.sponsorshipThe study received financial support from the Trakya University Scientific Research Support Fund.en_US
dc.identifier.doi10.1111/bjd.15185
dc.identifier.endpage1557en_US
dc.identifier.issn0007-0963
dc.identifier.issn1365-2133
dc.identifier.issue6en_US
dc.identifier.pmid27864821en_US
dc.identifier.scopus2-s2.0-85017592261en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1549en_US
dc.identifier.urihttps://doi.org/10.1111/bjd.15185
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24990
dc.identifier.volume176en_US
dc.identifier.wosWOS:000402794200044en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofBritish Journal Of Dermatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectExpressionen_US
dc.subjectHeat-Shock-Protein-60en_US
dc.subjectPathogenesisen_US
dc.subjectPrevalenceen_US
dc.subjectProteinsen_US
dc.subjectDeathen_US
dc.subjectRisken_US
dc.titleEffect of alterations in apoptotic pathway on development of metabolic syndrome in patients with psoriasis vulgarisen_US
dc.typeArticleen_US

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