The Role of Matrix Metalloproteinase-1 (-1607 1G/2G) Gene Variation in Ischemic Stroke Development

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dc.authoridKEHAYA, Sezgin/0000-0002-9608-9278
dc.authoridKEHAYA, Sezgin/0000-0002-9608-9278
dc.authorwosidKEHAYA, Sezgin/GVU-6069-2022
dc.authorwosidAlkanli, Nevra/D-4400-2019
dc.authorwosidKEHAYA, Sezgin/N-9995-2017
dc.contributor.authorAlkanli, Nevra
dc.contributor.authorAy, Arzu
dc.contributor.authorKehaya, Sezgin
dc.date.accessioned2024-06-12T11:07:07Z
dc.date.available2024-06-12T11:07:07Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The matrix metalloproteinase (MMP) family is a potential genetic risk factor for the development of cerebrovascular disease, including ischemic stroke. MMP-1 (-1607 1G/2G) gene variation can lead to excessive MMP-1 protein production and MMP-1 enzyme activity. MMPs have an important role in the pathophysiology ischemic stroke pathophysiology and clinical outcome. Thus, the sensitivity to ischemic stroke may vary according to genetic characteristics. The objective of this study was to investigate the effect of MMP-1 (-1607 1G/2G) gene variation in the development of ischemic stroke disease in the population of Thrace, Turkey. Materials and Methods: In all, 87 ischemic stroke patients and 80 healthy controls were enrolled in the study. Polymerase chain reaction and restriction fragment length polymorphism methods were used to determine the genotype distribution of MMP-1 (-1607 1G/2G) gene variations. Results: There were more 1G/1G genotype (56.9%) and 1G/2G genotypes (55.1%) of MMP-1 (-1607 1G/2G) gene variations in the patient group than in the control group. However, no significant difference was determined between the groups in the distribution of MMP-1 (-1607 1G/2G) gene variation genotypes (p=0.127). The allele frequency of MMP-1 (-1607 1G/2G) gene variation in the ischemic stroke patient and healthy control groups was not significantly different from the Hardy-Weinberg distribution (p=0.6556 and p=0.0501, respectively). Conclusion: The 1G/1G and 1G/2G genotypes of MMP-1 (-1607 1G/2G) gene variation were observed more frequently in the ischemic stroke group compared with the healthy control group. However, the MMP-1 (-1607 1G/2G) gene variation was not determined to be a genetic risk factor for the development of ischemic stroke in the population of Thrace region of Turkey.en_US
dc.identifier.doi10.14744/etd.2021.87012
dc.identifier.endpage25en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue1en_US
dc.identifier.startpage20en_US
dc.identifier.trdizinid520994en_US
dc.identifier.urihttps://doi.org/10.14744/etd.2021.87012
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/520994
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21902
dc.identifier.volume44en_US
dc.identifier.wosWOS:000762940500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherErciyes Univ Sch Medicineen_US
dc.relation.ispartofErciyes Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemic Strokeen_US
dc.subjectMatrix Metalloproteinasesen_US
dc.subjectPolymerase Chain Reactionen_US
dc.subjectPolymorphismen_US
dc.subjectRestriction Fragment Lengthen_US
dc.subjectPolymorphismsen_US
dc.titleThe Role of Matrix Metalloproteinase-1 (-1607 1G/2G) Gene Variation in Ischemic Stroke Developmenten_US
dc.typeArticleen_US

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