The role of nitric oxide in the protective effect of insulin against pentylenetetrazole-induced seizures in mice

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authoridDost, Turhan/0000-0001-7547-3310
dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.authorwosidDost, Turhan/B-3088-2012
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorUlugol, A
dc.contributor.authorArikan, E
dc.contributor.authorDost, T
dc.contributor.authorDokmeci, D
dc.contributor.authorKaradag, HC
dc.contributor.authorDokmeci, I
dc.date.accessioned2024-06-12T11:09:13Z
dc.date.available2024-06-12T11:09:13Z
dc.date.issued2000
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBoth insulin, depending on the glycemic state, and nitric oxide (NO), depending on the experimental conditions, have been suggested to have either proconvulsant or anticonvulsant effects. It is also known that NO plays an important role in some of the peripheral effects of insulin. The aim of the present study was to investigate the effects of NO and insulin against convulsions produced by pentylenetetrazole (PTZ, 60 mg/kg, i.p.) in mice and whether NO plays a role in the effect of insulin. Nitric oxide synthase (NOS) inhibitor, N-G-nitro-L-arginine-methyl ester (L-NAME, 1-100 mg/kg, i.p.) shortened the onset of PTZ-induced convulsions and increased the incidence and mortality rate, at the higher doses. Insulin (1 U/kg, i.p.), when given with dextrose (3 g/kg, i.p.) to counteract the hypoglycemic effect of the hormone, prolonged the onset of convulsions and decreased the incidence and mortality rate. L-NAME pretreatment (3 mg/kg, i.p.), at the dose which it produced no effect on PTZ-induced convulsions, attenuated the protective effect of 1 U/kg insulin + 3 g/kg dextrose combination significantly. Concomitant administration of the NO synthesis precursor, L-arginine (500 mg/kg), completely reversed this facilitatory effect of L-NAME. Our results indicate that NO has a protective effect against PTZ-induced convulsions in mice; insulin has a similar effect when given with dextrose; and, NO production may play an important role in the anticonvulsant effect of insulin.en_US
dc.identifier.doi10.1002/(SICI)1520-6769(200003/04)26:2<87
dc.identifier.endpage91en_US
dc.identifier.issn0893-6609
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-0034063175en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage87en_US
dc.identifier.urihttps://doi.org/10.1002/(SICI)1520-6769(200003/04)26:2<87
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22730
dc.identifier.volume26en_US
dc.identifier.wosWOS:000086771600003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons Ltden_US
dc.relation.ispartofNeuroscience Research Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNitric Oxideen_US
dc.subjectInsulinen_US
dc.subjectL-NAMEen_US
dc.subjectPentylenetetrazoleen_US
dc.subjectConvulsionsen_US
dc.subjectAcid-Induced Seizuresen_US
dc.subjectInhibits Pentylenetetrazoleen_US
dc.subjectSkeletal-Muscleen_US
dc.subjectRat Hippocampusen_US
dc.subjectBrainen_US
dc.subjectSynthaseen_US
dc.subjectReceptorsen_US
dc.subjectHypoglycemiaen_US
dc.subjectTransporten_US
dc.subjectCellsen_US
dc.titleThe role of nitric oxide in the protective effect of insulin against pentylenetetrazole-induced seizures in miceen_US
dc.typeArticleen_US

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