The other side of the coin: understanding noninvasive follicular tumor with papillary-like nuclear features in unifocal and multifocal settings

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dc.authoridCanberk, Sule/0000-0002-3736-1323
dc.authoridFelizardo, Diana Montezuma/0000-0001-9551-4589
dc.authoridSoares, Paula/0000-0001-9607-6998
dc.authoridCanberk, Sule/0000-0002-3736-1323
dc.authoridSchmitt, Fernando/0000-0002-3711-8681
dc.authorwosidCanberk, Sule/AAL-5645-2020
dc.authorwosidFelizardo, Diana Montezuma/AAF-7197-2021
dc.authorwosidSoares, Paula/B-6054-2008
dc.authorwosidCanberk, Sule/AAM-8781-2020
dc.authorwosidSchmitt, Fernando/A-5270-2008
dc.contributor.authorCanberk, Sule
dc.contributor.authorMontezuma, Diana
dc.contributor.authorTastekin, Ebru
dc.contributor.authorGrangeia, Diana
dc.contributor.authorDemirhas, Mehmet Polat
dc.contributor.authorAkbas, Meryem
dc.contributor.authorTokat, Fatma
dc.date.accessioned2024-06-12T11:09:12Z
dc.date.available2024-06-12T11:09:12Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe recent description of noninvasive follicular tumor with papillary-like nuclear features (NIFTP) creates several diagnostic and therapeutic challenges for both the pathologist and the attending clinician. Given the concern about overtreatment of these neoplasms, the best way to manage the patients by a surgical procedure and postsurgical follow-up is still under discussion. We aimed to identify predictors of synchronous disease (eg, bilateral cancers) that can influence the appropriate type of surgery and long-term surveillance. We reevaluated the original diagnosis and the presence of contralateral lesions in 94 cases retrieved from our archives that were seen between 2010 and 2017. In 74 cases, the diagnosis was NIFTP, and in 20 cases, the diagnosis was infiltrative follicular variant of papillary thyroid carcinoma (IFVPTC). Bilateral disease was found in 17% of the cases. In 13 (18%) of those cases, NIFTP was the primary lesion, and in 3 (15%), it was IFVPTC. The contralateral disease was predominantly invasive: 6 cases of micropapillary carcinoma, 5 of papillary thyroid carcinoma, 3 of IFVPTC, and 2 of NIFTP. Despite the higher frequency of contralateral disease in NIFTP, there was no statistically significant difference with IFVPTC. In the patients with multifocal NIFTP, 2 (15%) of the contralateral malignancies showed microscopic extrathyroidal extension (P < .05). We conclude that close monitoring of the contralateral lobe is appropriate in patients with FVPTC, particularly NIFTP, if they are not submitted to total thyroidectomy. (C) 2018 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipNorte Portugal Regional Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000003]en_US
dc.description.sponsorshipWe thank Manuela Felizardo for editing of the images. Prof. Fernando Schmitt was partially supported by the project NORTE-01-0145-FEDER-000003, supported by Norte Portugal Regional Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).en_US
dc.identifier.doi10.1016/j.humpath.2018.10.040
dc.identifier.endpage142en_US
dc.identifier.issn0046-8177
dc.identifier.issn1532-8392
dc.identifier.pmid30529753en_US
dc.identifier.scopus2-s2.0-85062705507en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage136en_US
dc.identifier.urihttps://doi.org/10.1016/j.humpath.2018.10.040
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22719
dc.identifier.volume86en_US
dc.identifier.wosWOS:000466261000017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofHuman Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNIFTPen_US
dc.subjectFVPTCen_US
dc.subjectContralateral Lesionsen_US
dc.subjectThyroiden_US
dc.subjectEncapsulated Tumorsen_US
dc.subjectPathologyen_US
dc.subjectMultifocalityen_US
dc.subjectDifferentiated Thyroid-Canceren_US
dc.subjectCompletion Thyroidectomyen_US
dc.subjectAssociation Guidelinesen_US
dc.subjectTask-Forceen_US
dc.subjectCarcinomaen_US
dc.subjectVarianten_US
dc.subjectNeoplasmen_US
dc.subjectManagementen_US
dc.subjectFrequencyen_US
dc.subjectNodulesen_US
dc.titleThe other side of the coin: understanding noninvasive follicular tumor with papillary-like nuclear features in unifocal and multifocal settingsen_US
dc.typeArticleen_US

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