Myrtle improves renovascular hypertension-induced oxidative damage in heart, kidney, and aortic tissue

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dc.authoridSaygi, Halil Ibrahim/0000-0001-8736-3282
dc.authoridTunali Akbay, Tugba/0000-0002-2091-9298
dc.authoridGöger, Fatih/0000-0002-9665-0256
dc.authoridSener, Goksel/0000-0001-7444-6193
dc.authorwosidSaygi, Halil Ibrahim/G-3563-2013
dc.authorwosidYakut, Zatiye Ayça Çevikelli/ACP-2487-2022
dc.authorwosidTunali Akbay, Tugba/AAS-4127-2020
dc.authorwosidGöger, Fatih/HTR-3454-2023
dc.contributor.authorArslan, Sule
dc.contributor.authorOzcan, Ozan
dc.contributor.authorGurel-Gokmen, Begum
dc.contributor.authorCevikelli-Yakut, Zatiye Ayca
dc.contributor.authorSaygi, Halil Ibrahim
dc.contributor.authorSen, Ali
dc.contributor.authorGoger, Fatih
dc.date.accessioned2024-06-12T11:13:36Z
dc.date.available2024-06-12T11:13:36Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractRenovascular hypertension is defined as the reduction in renal perfusion resulting in sustained hypertension. This study aims to investigate the possible effects of myrtle leaf extract (Myrtus communis L.) on, heart, kidney and aorta tissues in the experimental renovascular hypertension (RVH). 32 male Wistar Albino rats were divided into four groups as control, hypertension, hypertension+ramipril, and hypertension+myrtle leaf extract treatment groups. RVH model was induced by Goldblatt's 2-kidney 1-clip method. 12 weeks later than the treatment blood pressures were recorded and oxidant and antioxidant parameters, tissue factor activity, and histological analysis were determined in the kidney, heart, and aortic tissues. The blood pressure levels of the hypertension group significantly increased compared to the control group. Administration of myrtle leaf extract and ramipril significantly decreased the increased blood pressure. In the hypertension group, oxidative damage increased in the kidney, heart, and aorta tissues. In the histological evaluation of tissues in RVH, heart muscle fibres degenerated. Bowman capsule and glomeruli dilated and tubules damaged in the kidney. Myrtle leaf extract administration regenerated the damages and degenerations. The administration of myrtle leaf extract restored the impaired oxidant-antioxidant balance in the heart, kidney and aorta tissues of hypertensive rats. Myrtle leaf extract can be considered as an alternative antihypertensive treatment target in the prevention of oxidative stress-induced damage in renovascular hypertension.en_US
dc.description.sponsorshipMarmara University Scientific Research Project Department [SAG-C-YLP-170419-0142]en_US
dc.description.sponsorshipThis study was funded by a grant from Marmara University Scientific Research Project Department (Project ID: SAG-C-YLP-170419-0142).en_US
dc.identifier.doi10.1007/s11756-022-01039-1
dc.identifier.endpage1888en_US
dc.identifier.issn0006-3088
dc.identifier.issn1336-9563
dc.identifier.issue7en_US
dc.identifier.scopus2-s2.0-85125590108en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1877en_US
dc.identifier.urihttps://doi.org/10.1007/s11756-022-01039-1
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23598
dc.identifier.volume77en_US
dc.identifier.wosWOS:000763853900001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofBiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRenovascular Hypertensionen_US
dc.subjectMyrtus Communis Len_US
dc.subjectMyrtle Leaf Extracten_US
dc.subjectOxidative Stressen_US
dc.subjectPhenolic-Compoundsen_US
dc.subjectBlood-Pressureen_US
dc.subjectCommunisen_US
dc.subjectStressen_US
dc.subjectAntioxidanten_US
dc.subjectLeavesen_US
dc.subjectPathophysiologyen_US
dc.subjectIdentificationen_US
dc.titleMyrtle improves renovascular hypertension-induced oxidative damage in heart, kidney, and aortic tissueen_US
dc.typeArticleen_US

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