Increased basic fibroblast growth factor levels in serum and blister fluid from patients with vitiligo

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dc.authorwosidTuzun, Yalcin/B-6333-2015
dc.contributor.authorÖzdemir, M
dc.contributor.authorYillar, G
dc.contributor.authorWolf, R
dc.contributor.authorYillar, O
dc.contributor.authorÜnal, G
dc.contributor.authorTüzün, B
dc.contributor.authorTüzün, Y
dc.date.accessioned2024-06-12T10:54:13Z
dc.date.available2024-06-12T10:54:13Z
dc.date.issued2000
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBasic fibroblast growth factor (bFGF) is a pleiotropic growth factor which has a high capacity for stimulating normal melanocyte proliferation and suppressing melanogenesis, The close and complicated relationship between bFGF, melanocyte proliferation and melanogenesis raises the theoretical possibility that bFGF may also be involved in the pathomechanism leading to vitiligo, The aim of this study was to compare the serum and suction blister fluid bFGF levels of vitiligo patients (9 females, 11 males) with those of healthy controls (3 females, 8 males). Vitiliginous skin-blister fluid bFGF levels and serum levels were significantly higher in vitiligo patients compared with healthy normal controls. Our data indicate that bFGF might be involved in the pathogenetic chain of events leading to vitiligo. Further studies are needed to define the exact role of bFGF and various other melanocytic mitogens in this disease.en_US
dc.identifier.endpage439en_US
dc.identifier.issn0001-5555
dc.identifier.issue6en_US
dc.identifier.pmid11243639en_US
dc.identifier.startpage438en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18975
dc.identifier.volume80en_US
dc.identifier.wosWOS:000166969300011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Asen_US
dc.relation.ispartofActa Dermato-Venereologicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBasic Fibroblast Growth Factoren_US
dc.subjectVitiligoen_US
dc.subjectHuman Melanocytesen_US
dc.subjectExpressionen_US
dc.subjectBfgfen_US
dc.subjectMelanogenesisen_US
dc.subjectMelanomaen_US
dc.subjectMitogensen_US
dc.titleIncreased basic fibroblast growth factor levels in serum and blister fluid from patients with vitiligoen_US
dc.typeArticleen_US

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