Pendrin and sodium/iodide symporter protein expression in the testicular tissue of normal and diabetic rats in prepubertal and post pubertal stages

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dc.authoridKARACA, Turan/0000-0002-2500-7781
dc.authorwosiddemirtaş, selim/JED-6784-2023
dc.authorwosidKARACA, Turan/ABD-6669-2020
dc.contributor.authorKaraca, T.
dc.contributor.authorDemirtas, S.
dc.contributor.authorGoren, Uzun D.
dc.date.accessioned2024-06-12T10:59:26Z
dc.date.available2024-06-12T10:59:26Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPendrin (PDS) and sodium/iodide symporter (NIS) are transmembrane proteins that are located in numerous tissue types, particularly thyroid follicular epithelial cells, where they are entrusted with the regulation of iodine molecules. In the present study, we aimed to clarify changes in PDS and NIS protein expression, in the testicular tissue of prepubertal and post pubertal rats at normal or diabetic conditions. Forty Wistar albino male rats (20 prepubertal and 20 post pubertal) were divided into four groups, as follows: group I was prepubertal control, group II was prepubertal diabetic (60 mg/kg intraperitoneal [ip] streptozotocin [STZ]), group III was post pubertal control, and group IV was post pubertal diabetic (60 mg/kg ip STZ). Ki67 immunoreactivity decreased in testicular tissue of both the prepubertal and post pubertal diabetic groups; the apoptotic tubule index and apoptotic cell number increased in the diabetic groups as compared to the control groups. Pendrin immunoreactivity was detected in seminiferous tubules and Leydig cells; and was significantly reduced in the diabetic groups (P<0.05). The number of cells positive for NIS was significantly decreased in prepubertal and post pubertal rats with diabetes, compared to the controls. Enzyme-linked immunosorbent assay (ELISA) analysis showed that PDS and NIS values were significantly reduced in the prepubertal and post pubertal diabetic groups as compared to the control groups. Our results indicate a potential relationship between puberty and PDS and NIS expression in rat testicular tissue and showed the decreasing effects of diabetes on PDS and NIS expression in testicular tissues in rats.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK-ARDEB-SBAG-115S689]en_US
dc.description.sponsorshipThis work was supported by the Scientific and Technological Research Council of Turkey (TUBITAK-ARDEB-SBAG-115S689).en_US
dc.identifier.endpage261en_US
dc.identifier.issn1728-1997
dc.identifier.issue4en_US
dc.identifier.pmid30774665en_US
dc.identifier.scopus2-s2.0-85059322066en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage255en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20449
dc.identifier.volume19en_US
dc.identifier.wosWOS:000453587000002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherShiraz Univen_US
dc.relation.ispartofIranian Journal Of Veterinary Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectPendrinen_US
dc.subjectRaten_US
dc.subjectSodium/Iodide Symporteren_US
dc.subjectTestisen_US
dc.subjectSyndrome Geneen_US
dc.subjectBreasten_US
dc.titlePendrin and sodium/iodide symporter protein expression in the testicular tissue of normal and diabetic rats in prepubertal and post pubertal stagesen_US
dc.typeArticleen_US

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