The Evaluation of In Vitro Effects of Dipyridamole on Coronary Artery Bypass Grafts

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dc.authoridKaradag, Cetin Hakan/0000-0002-4763-986X
dc.authorwosidgur, ozcan/AAA-8847-2022
dc.authorwosidGurkan, Selami/AAA-9006-2022
dc.authorwosidKaradag, Cetin Hakan/H-4899-2013
dc.contributor.authorEge, Turan
dc.contributor.authorKaraca, Okay Guven
dc.contributor.authorGur, Ozcan
dc.contributor.authorKaradag, Hakan
dc.contributor.authorGurkan, Selami
dc.contributor.authorDuran, Enver
dc.date.accessioned2024-06-12T10:59:38Z
dc.date.available2024-06-12T10:59:38Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The aim of this study is to evaluate the efficacy of dipyridamole in relieving the vasospasm of coronary artery bypass grafts. Material and Methods: Twenty two patients who underwent elective coronary artery bypass grafting (CABG) were admitted to the study (Men/Women:14/8, mean age: 62.4 +/- 8.8 years). Ten samples from left internal mammary(LIMA), radial arterial (RA) and saphenous vein (SV) grafts were collected for each. The samples were transported to the vascular laboratory in 4 C Krebs solution. Submaximal smooth muscle contraction was achieved first by 10-7M of phenylephrine solution. Dipyridamole was then added, starting from a concentration of 10-9M to a concentration of 10-3.5M in two minutes intervals and half logarithmic dose increments. The concentration-response curves were obtained of the vasodilatation response relative to the begining. Results: In the LIMA graft samples, the vasodilation response to dipyridamole was 43.2 +/- 1.6% and 97.6 +/- 4.1% at concentrations of 10-6M and 10-3.5M respectively. In RA graft samples, the vasodilation response to dipyridamole was 36.3 +/- 1.8% and 95.3 +/- 2.7% at concentrations of 10-6M and 10-3.5M respectively. In SV graft samples, however, the vasodilation response to dipyridamole was 43.2 +/- 1.4% and 96.6 +/- 2.2% at concentrations of 10-6M and 10-3.5M respectively. Conclusions: The amplitude of relaxation response to dipyridamole of all grafts samples were similar, without statistically significant difference among the IMA, RA and SV grafts in the in vitro tissue bath system. These results prove that dipyridamole has a potential use as a vasodilatatory drug in all graft types.en_US
dc.identifier.doi10.5174/tutfd.2010.04129.2
dc.identifier.endpage263en_US
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-80053352402en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage261en_US
dc.identifier.urihttps://doi.org/10.5174/tutfd.2010.04129.2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20515
dc.identifier.volume28en_US
dc.identifier.wosWOS:000295492900007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofBalkan Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectDipyridamoleen_US
dc.subjectCoronary Artery Bypass Graften_US
dc.subjectLeft Internal Mammarian Arteryen_US
dc.subjectRadial Arteryen_US
dc.subjectSaphenous Veinen_US
dc.subjectInternal Mammary Arteryen_US
dc.subjectFlowen_US
dc.titleThe Evaluation of In Vitro Effects of Dipyridamole on Coronary Artery Bypass Graftsen_US
dc.typeArticleen_US

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