Hypercoagulopathy in stroke patients with nonvalvular atrial fibrillation

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dc.authorwosidTurgut, Burhan/A-2517-2016
dc.contributor.authorTurgut, N
dc.contributor.authorAkdemir, O
dc.contributor.authorTurgut, B
dc.contributor.authorDemir, M
dc.contributor.authorEkuklu, G
dc.contributor.authorVural, Ö
dc.contributor.authorÖzbay, G
dc.date.accessioned2024-06-12T11:09:21Z
dc.date.available2024-06-12T11:09:21Z
dc.date.issued2006
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe coagulation system is activated and coagulation activation markers are elevated in acute ischemic stroke with nonvalvular atrial fibrillation (NVAF). The etiology, severity, and prognosis of the ischemic stroke might be estimated with the level of the activation of the coagulation system. In this study, prothrombin F1+2 (F1+2), D-dimer, and fibrinogen levels were measured in patients with acute ischemic stroke with and without NVAF, and stroke severity was compared with these hemostatic parameters. Of 55 patients, 29 had sinus rhythm (group I), 26 had NVAF (group II); 20 healthy subjects (group III) were included in the study. Subtypes of cerebral infarction were classified. The patients underwent stroke severity, electrocardiography, echocardiography, cranial computed tomography, cervical duplex ultrasonography, and hemostatic parameter studies. In group II, F1+2 level (2.83 +/- 0.89) was significantly higher than in group I (2.33 +/- 0.80) and III (1.94 +/- 0.64) (p values: group I-II, 0.036; groups II-III, 0.001; groups I-III, 0.104). In group III, fibrinogen level (251.64 +/- 60.96) was significantly lower than that in groups I (347.97 +/- 111.49) and II (364.04 +/- 86.20) (p = 0.001). D-dimer was not significantly different between groups. In group I, lacunar syndrome (LACS), and in group II, partial and total anterior circulation syndrome (PACS + TAGS) were more common (p = 0.013, p = 0.001, respectively). In group II, Scandinavian Stroke Scale scores were lower than those in group I (group I = 45.2 +/- 14, group II = 35.4 +/- 18.9, p = 0.02). In conclusion, activation of coagulation, demonstrated by increment F1+2, is more abundant in the stroke patients with NVAF than in the stroke patients with sinus rhythm. Our results also showed that activation of the hemostatic system might be related to stroke subtype and stroke severity. It is suggested that the oral anticoagulation treatment as prophylaxis is important in the prevention of stroke in patients with NVAFen_US
dc.identifier.doi10.1177/107602960601200104
dc.identifier.endpage20en_US
dc.identifier.issn1076-0296
dc.identifier.issue1en_US
dc.identifier.pmid16444430en_US
dc.identifier.scopus2-s2.0-32344453629en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://doi.org/10.1177/107602960601200104
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22782
dc.identifier.volume12en_US
dc.identifier.wosWOS:000235089800004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWestminster Publ Incen_US
dc.relation.ispartofClinical And Applied Thrombosis-Hemostasisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNonvalvular Atrial Fibrillationen_US
dc.subjectIschemic Strokeen_US
dc.subjectProthrombin Fragment 1+2en_US
dc.subjectEchocardiographyen_US
dc.subjectAcute Ischemic-Strokeen_US
dc.subjectHemostatic Markersen_US
dc.subjectIncreased Risken_US
dc.subjectThromboembolismen_US
dc.subjectCoagulationen_US
dc.subjectPredictorsen_US
dc.subjectActivationen_US
dc.subjectFeaturesen_US
dc.subjectSubtypesen_US
dc.subjectAspirinen_US
dc.titleHypercoagulopathy in stroke patients with nonvalvular atrial fibrillationen_US
dc.typeArticleen_US

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