DIFFERENTIAL ROLE OF NUCLEUS-ACCUMBENS AND CAUDATE-PUTAMEN IN MEDIATING THE EFFECT OF NOMIFENSINE AND METHAMPHETAMINE ON AMBULATION AND REARING OF RATS IN THE OPEN-FIELD TEST

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dc.contributor.authorALKHATIB, IMH
dc.contributor.authorDOKMECI, I
dc.contributor.authorFUJIWARA, M
dc.date.accessioned2024-06-12T11:09:15Z
dc.date.available2024-06-12T11:09:15Z
dc.date.issued1995
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe effects of nomifensine (NOM) and methamphetamine (MA) on ambulation and rearing of rats in the open-field test were investigated. NOM and MA were injected i.p. into intact rats and nucleus accumbens (ACC)- and caudate-putamen (CP)-lesioned rats and infused into the ACC and CP. NOM (1-10 mg/kg, i.p.) and MA (1-5 mg/kg, i.p.) produced hyperactivity. However, NOM at 20 mg/kg, i.p. decreased the activity and induced repetitive head bobbing and squatting. Lesions of the ACC and CP increased open-field activity. However, lesion of the CP increased rearing more than lesion of the ACC. The increase in ambulation induced by NOM was inhibited by lesion of the ACC, whereas that induced by MA was inhibited by lesion of the CP. Although NOM (1-10 mu g/2 mu l) and MA (0.5-10 mu g/2 mu l) injections into the ACC and CP induced hyperactivity, the effect of NOM was greater after injection into the ACC, whereas the effect of MA was greater following injection into the CP. These results suggest that the ACC has a greater role in ambulation, while CP has a greater one in rearing. The present results, while they verified the significance of the ACC and CP in NOM- and MA-hyperactivity, also revealed a differential role of the ACC in NOM-hyperactivity and the CP in MA-hyperactivity.en_US
dc.identifier.doi10.1254/jjp.67.69
dc.identifier.endpage77en_US
dc.identifier.issn0021-5198
dc.identifier.issue1en_US
dc.identifier.pmid7745847en_US
dc.identifier.scopus2-s2.0-0028888486en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage69en_US
dc.identifier.urihttps://doi.org/10.1254/jjp.67.69
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22744
dc.identifier.volume67en_US
dc.identifier.wosWOS:A1995QE71100010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJapanese Pharmacological Socen_US
dc.relation.ispartofJapanese Journal Of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNOMIFENSINEen_US
dc.subjectMETHAMPHETAMINEen_US
dc.subjectNUCLEUS ACCUMBENSen_US
dc.subjectCAUDATE-PUTAMENen_US
dc.subjectHYPERACTIVITYen_US
dc.subjectInduced Dopamine Releaseen_US
dc.subjectFreely Moving Ratsen_US
dc.subjectBrain Catecholaminesen_US
dc.subjectCorpus Striatumen_US
dc.subjectMotor-Activityen_US
dc.subjectAmphetamineen_US
dc.subjectMiceen_US
dc.subjectLesionsen_US
dc.subjectCocaineen_US
dc.subjectMicrodialysisen_US
dc.titleDIFFERENTIAL ROLE OF NUCLEUS-ACCUMBENS AND CAUDATE-PUTAMEN IN MEDIATING THE EFFECT OF NOMIFENSINE AND METHAMPHETAMINE ON AMBULATION AND REARING OF RATS IN THE OPEN-FIELD TESTen_US
dc.typeArticleen_US

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