Comparison of serum BDNF, IL-1?, IL-6, TNF-?, CRP and leucocyte levels in unipolar mania and bipolar disorder

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dc.authoridGorgulu, Yasemin/0000-0002-3401-4879
dc.authorwosidGorgulu, Yasemin/S-4355-2017
dc.contributor.authorGorgulu, Yasemin
dc.contributor.authorUluturk, Milkibar Kyazim
dc.contributor.authorPalabiyik, Orkide
dc.date.accessioned2024-06-12T10:54:43Z
dc.date.available2024-06-12T10:54:43Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Unipolar mania is not included in the diagnostic and statistical manual of mental disorders-5 (DSM-5) as a separate diagnosis, although it is defined by widely accepted diagnostic criteria. The aim of this study was to investigate the differences between unipolar mania and bipolar disorder in terms of clinical and inflammatory parameters. Methods: The data of 495 hospitalised patients with bipolar disorder diagnoses were analysed retrospectively. Forty met the diagnostic criteria for unipolar mania. Two patients refused to participate in the study. Thirty-eight unipolar mania patients and 42 randomly selected patients with bipolar disorder diagnosis were included in the study. The two groups were compared in terms of sociodemographic, clinical characteristics, serum brain-derived neurotrophic factor, C-reactive protein (CRP), leucocyte and cytokine levels. Results: A total of 40 (8.08%) of 495 patients diagnosed with bipolar disorder met the unipolar mania diagnostic criteria. The number of manic episodes and the number of hospitalisations were statistically higher in the unipolar mania group than in the bipolar disorder group. Among all the manic symptoms, the incidence of symptoms such as euphoria, increased sexual interest, grandiosity and delusions were found to be statistically higher in the unipolar mania group. Interleukin (IL)-6 and CRP levels were significantly higher in the unipolar mania group than in the bipolar disorder group. Conclusion: Unipolar mania differs from bipolar disorder in terms of clinical features and serum IL-6 and CRP levels.en_US
dc.description.sponsorshipTrakya University Scientific Research Project Committee [TUBAP2018/06]en_US
dc.description.sponsorshipThis work was supported by a research grant from Trakya University Scientific Research Project Committee (grant number: TUBAP2018/06). This work was not an industry-supported study. Each author declares that they have no financial conflict of interest.en_US
dc.identifier.doi10.1017/neu.2021.25
dc.identifier.endpage322en_US
dc.identifier.issn1601-5215
dc.identifier.issue6en_US
dc.identifier.pmid34462030en_US
dc.identifier.scopus2-s2.0-85114339596en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage317en_US
dc.identifier.urihttps://doi.org/10.1017/neu.2021.25
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19159
dc.identifier.volume33en_US
dc.identifier.wosWOS:000727554600004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofActa Neuropsychiatricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBipolar Disorderen_US
dc.subjectManiaen_US
dc.subjectBrain-Derived Neurotrophic Factoren_US
dc.subjectC-Reactive Proteinen_US
dc.subjectInterleukin 1betaen_US
dc.subjectInterleukin-6en_US
dc.subjectTumour Necrosis Factor-Alphaen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectI Disorderen_US
dc.subjectNeurotrophic Factoren_US
dc.subjectCytokinesen_US
dc.titleComparison of serum BDNF, IL-1?, IL-6, TNF-?, CRP and leucocyte levels in unipolar mania and bipolar disorderen_US
dc.typeArticleen_US

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